X0206 3 2024-11-01 0 0001597553 Sage Therapeutics, Inc. SAGE 0002041689 Shiferman Gregory L. C/O SAGE THERAPEUTICS, INC. 55 CAMBRIDGE PARKWAY CAMBRIDGE MA 02142 false true false false See Remarks Common Stock 14967.00 D Stock Option (Right to buy) 23.02 2034-02-12 Common Stock 6000.00 D Stock Option (Right to buy) 22.20 2031-02-21 Common Stock 20608.00 D Consists of (i) 153 shares of Common Stock and (ii) 14,814 shares of Common Stock issuable under restricted stock units ("RSUs") awarded to the Reporting Person pursuant to the Sage Therapeutics, Inc. 2014 Stock Option and Incentive Plan (the "Plan") that vest periodically subject to the Reporting Person's continued service. Each RSU represents the right to receive one share of Common Stock upon vesting. This option was granted on February 13, 2024, pursuant to the Plan. The shares underlying the option vest over four years, with 25% of the shares vesting on February 13, 2025, and the remaining shares vesting in equal monthly installments thereafter, subject to the Reporting Person's continued service. This option was granted on February 21, 2024, pursuant to the Plan. The shares underlying the option vest in equal monthly installments over 18 months, with the first installment vesting on March 21, 2024, and the remaining shares vesting in equal monthly installments thereafter, subject to the Reporting Person's continued service. Senior Vice President, General Counsel and Secretary Exhibit Index: 24.1 Power of Attorney Brandon Marsh, attorney in fact for Gregory Shiferman 2024-11-01