X0508 4 2024-10-15 0 0000874015 IONIS PHARMACEUTICALS INC IONS 0002037721 Devers Shannon L. 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 EVP, Chief Human Resources Ofc 0 Restricted Stock Unit 0.0 2024-10-15 4 A 0 11280 0.0 A Common Stock 11280 42521 D Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. By: Patrick R. O'Neil, attorney-in-fact For: Shannon L. Devers 2024-10-16