X0206 3 2024-09-29 0 0000874015 IONIS PHARMACEUTICALS INC IONS 0002037721 Devers Shannon L. 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 EVP, Chief Human Resourses Ofc Common Stock 7909 D Non-Qualified Stock Option (right to buy) 32.6 2023-01-03 2032-01-02 Common Stock 14368 D Non-Qualified Stock Option (right to buy) 37.58 2024-01-03 2033-01-02 Common Stock 15317 D Non-Qualified Stock Option (right to buy) 48.51 2021-04-05 2027-04-04 Common Stock 6000 D Non-Qualified Stock Option (right to buy) 49.25 2019-01-02 2025-01-01 Common Stock 16042 D Non-Qualified Stock Option (right to buy) 52.87 2020-01-02 2034-01-01 Common Stock 18526 D Non-Qualified Stock Option (right to buy) 53.77 2020-01-02 2026-01-01 Common Stock 16777 D Non-Qualified Stock Option (right to buy) 56.78 2022-01-04 2028-01-03 Common Stock 28516 D Non-Qualified Stock Option (right to buy) 60.89 2021-01-02 2027-01-01 Common Stock 17125 D Restricted Stock Unit 0.0 Common Stock 31241 D Each restricted stock unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Grants to reporting person of restricted stock units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan on January 15, 2021, January 15, 2022, January 15, 2023 and January 15, 2024. The restricted stock units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. By: Patrick R. O'Neil, attorney-in-fact For: Shannon L. Devers 2024-10-01