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          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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    <issuerInfo>
      <issuerCik>0002036042</issuerCik>
      <issuerName>Sionna Therapeutics, Inc.</issuerName>
      <secFileNumber>001-42504</secFileNumber>
      <issuerAddress>
        <com:street1>21 Hickory Drive</com:street1>
        <com:street2>Suite 500</com:street2>
        <com:city>Waltham</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02451</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>6178192020</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Atlas Venture Opportunity Fund II,  L.P.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Shareholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>555 California Street</com:street1>
          <com:street2>18th Floor</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94104</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>15418</noOfUnitsSold>
      <aggregateMarketValue>496459.6</aggregateMarketValue>
      <noOfUnitsOutstanding>44139823</noOfUnitsOutstanding>
      <approxSaleDate>10/21/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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      <acquiredDate>03/04/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Private Placement</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>15418</amountOfSecuritiesAcquired>
      <paymentDate>03/04/2024</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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      <sellerDetails>
        <name>Atlas Venture Opportunity Fund II, L.P.</name>
        <address>
          <com:street1>400 Technology Sq.</com:street1>
          <com:street2>10th Floor</com:street2>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>09/29/2025</saleDate>
      <amountOfSecuritiesSold>11468</amountOfSecuritiesSold>
      <grossProceeds>345080.15</grossProceeds>
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      <sellerDetails>
        <name>Atlas Venture Opportunity Fund II, L.P.</name>
        <address>
          <com:street1>400 Technology Sq.</com:street1>
          <com:street2>10th Floor</com:street2>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </address>
      </sellerDetails>
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      <amountOfSecuritiesSold>2149</amountOfSecuritiesSold>
      <grossProceeds>64594.43</grossProceeds>
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          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </address>
      </sellerDetails>
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      <saleDate>10/01/2025</saleDate>
      <amountOfSecuritiesSold>35</amountOfSecuritiesSold>
      <grossProceeds>1048.25</grossProceeds>
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      <sellerDetails>
        <name>Atlas Venture Opportunity Fund II, L.P.</name>
        <address>
          <com:street1>400 Technology Sq.</com:street1>
          <com:street2>10th Floor</com:street2>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/03/2025</saleDate>
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      <grossProceeds>196451.79</grossProceeds>
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        <name>Atlas Venture Opportunity Fund II, L.P.</name>
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          <com:street1>400 Technology Sq.</com:street1>
          <com:street2>10th Floor</com:street2>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/06/2025</saleDate>
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      <grossProceeds>61430.47</grossProceeds>
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        <name>Atlas Venture Opportunity Fund II, L.P.</name>
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          <com:street1>400 Technology Sq.</com:street1>
          <com:street2>10th Floor</com:street2>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/10/2025</saleDate>
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      <grossProceeds>105273.82</grossProceeds>
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      <sellerDetails>
        <name>Atlas Venture Opportunity Fund II, L.P.</name>
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          <com:street1>400 Technology Sq.</com:street1>
          <com:street2>10th Floor</com:street2>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </address>
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      <amountOfSecuritiesSold>10102</amountOfSecuritiesSold>
      <grossProceeds>306888.66</grossProceeds>
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        <name>Atlas Venture Opportunity Fund II, L.P.</name>
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          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/14/2025</saleDate>
      <amountOfSecuritiesSold>105</amountOfSecuritiesSold>
      <grossProceeds>3144.75</grossProceeds>
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      <sellerDetails>
        <name>Atlas Venture Opportunity Fund II, L.P.</name>
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          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </address>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/15/2025</saleDate>
      <amountOfSecuritiesSold>20098</amountOfSecuritiesSold>
      <grossProceeds>615091.25</grossProceeds>
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        <name>Atlas Venture Opportunity Fund II, L.P.</name>
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          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </address>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/16/2025</saleDate>
      <amountOfSecuritiesSold>29363</amountOfSecuritiesSold>
      <grossProceeds>950063.36</grossProceeds>
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      <sellerDetails>
        <name>Atlas Venture Opportunity Fund II, L.P.</name>
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          <com:street1>400 Technology Sq.</com:street1>
          <com:street2>10th Floor</com:street2>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/17/2025</saleDate>
      <amountOfSecuritiesSold>10604</amountOfSecuritiesSold>
      <grossProceeds>343189.98</grossProceeds>
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    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Atlas Venture Opportunity Fund II, L.P.</name>
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          <com:stateOrCountry>MA</com:stateOrCountry>
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      <sellerDetails>
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    <noticeSignature>
      <noticeDate>10/21/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>02/25/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>Ommer Chohan</signature>
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