Exhibit 107

Calculation of Filing Fee Table

Form S-1

(Form Type)

Sionna Therapeutics, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

	Security Type	Security Class Title	Fee Calculation Rule	Maximum Aggregate Offering Price(1)(2)	Fee Rate	Amount of Registration Fee
Fees to Be Paid	Equity	Common Stock, par value $0.001 per share	457(o)	$100,000,000	0.00015310	$15,310.00
	Total Offering Amounts			$100,000,000		$15,310.00
	Total Fees Previously Paid					—
	Total Fee Offsets					—
	Net Fee Due					$15,310.00

⁽¹⁾  Estimated solely for the purpose of computing the registration fee in accordance with Rule 457(o) under the Securities Act of 1933, as amended.

⁽²⁾ Includes the aggregate offering price of additional shares that the underwriters have the option to purchase.