Exhibit 5.1

           [Letterhead of Phillips, Gardill, Kaiser & Altmeyer, PLLC]


                                 April 24, 2009


WesBanco, Inc.
One Bank Plaza
Wheeling, WV  26003

Ladies and Gentlemen:

     I am the Managing Member of Phillips,  Gardill, Kaiser & Altmeyer, PLLC and
our firm serves as general counsel for WesBanco, Inc. (the "Company") and I have
acted as counsel  for the  Company in  connection  with the  preparation  of the
Registration  Statement  on  Form  S-8 to be  filed  by  the  Company  with  the
Securities and Exchange Commission for the registration under the Securities Act
of 1933, as amended,  of an additional  750,000  shares of the Company's  common
stock, par value $2.0833 per share (the "Shares"),  which are to be offered from
time to time to certain employees of the Company pursuant to the WesBanco,  Inc.
KSOP (the "Plan").

     I have  examined  the  originals,  certified  copies  or  copies  otherwise
identified  to my  satisfaction  as being true copies of the Plan and such other
documents  as I have  deemed  necessary  or  appropriate  for  purposes  of this
opinion.

     Based on the foregoing,  I am of the opinion that the Shares have been duly
and validly  authorized  and reserved for  issuance,  and that the Shares,  when
issued under the terms of the Plan,  will be legally and validly  issued,  fully
paid and nonassessable.

     I hereby  consent  to the  filing of this  opinion  as  Exhibit  5.1 to the
Registration Statement.

                                                   Very truly yours,

                                                   /s/ James C. Gardill
                                                   -----------------------------
                                                   James C. Gardill