October 16, 2024

Jeffrey H. Jackson
Chief Executive Officer
Wesbanco, Inc.
1 Bank Plaza
Wheeling, West Virginia 26003

        Re: Wesbanco, Inc.
            Registration Statement on Form S-4
            Filed October 4, 2024
            File No. 333-282519
Dear Jeffrey H. Jackson:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Aisha Adegbuyi at 202-551-8754 with any questions.



                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Finance
cc:   James C. Gardill, Esq.