<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0002033974</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000907654</issuerCik>
            <issuerName>ORUKA THERAPEUTICS INC</issuerName>
            <secFileNumber>000-22873</secFileNumber>
            <issuerAddress>
                <ns2:street1>855 Oak Grove Avenue Suite 100</ns2:street1>
                <ns2:city>Menlo Park</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94025</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6506067910</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Arjun Agarwal</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>9999</noOfUnitsSold>
            <aggregateMarketValue>821017.89</aggregateMarketValue>
            <noOfUnitsOutstanding>66209699</noOfUnitsOutstanding>
            <approxSaleDate>10/12/2026</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/12/2026</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>9999</amountOfSecuritiesAcquired>
            <paymentDate>10/12/2026</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ARJUN AGARWAL</name>
                <address>
                    <ns2:street1>855 Oak Grove Avenue Suite 100</ns2:street1>
                    <ns2:city>Menlo Park</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94025</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/21/2026</saleDate>
            <amountOfSecuritiesSold>533</amountOfSecuritiesSold>
            <grossProceeds>51034.75</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ARJUN AGARWAL</name>
                <address>
                    <ns2:street1>855 Oak Grove Avenue Suite 100</ns2:street1>
                    <ns2:city>Menlo Park</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94025</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/15/2026</saleDate>
            <amountOfSecuritiesSold>560</amountOfSecuritiesSold>
            <grossProceeds>53597.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ARJUN AGARWAL</name>
                <address>
                    <ns2:street1>855 Oak Grove Avenue Suite 100</ns2:street1>
                    <ns2:city>Menlo Park</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94025</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/11/2026</saleDate>
            <amountOfSecuritiesSold>9459</amountOfSecuritiesSold>
            <grossProceeds>872413.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ARJUN AGARWAL</name>
                <address>
                    <ns2:street1>855 Oak Grove Avenue Suite 100</ns2:street1>
                    <ns2:city>Menlo Park</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94025</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/13/2026</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>1066571.87</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ARJUN AGARWAL</name>
                <address>
                    <ns2:street1>855 Oak Grove Avenue Suite 100</ns2:street1>
                    <ns2:city>Menlo Park</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94025</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/13/2026</saleDate>
            <amountOfSecuritiesSold>9999</amountOfSecuritiesSold>
            <grossProceeds>846180.51</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>Sales that were executed on October 12, 2026 are being reported on this Form 144 filed on October 13, 2026 given the EDGAR system was not accepting filings on October 12, 2026 in observance of the federal holiday.</remarks>
        <noticeSignature>
            <noticeDate>10/12/2026</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/11/2026</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Arjun Agarwal</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
