144 0002033974 XXXXXXXX LIVE 0000907654 Oruka Therapeutics, Inc. 000-22873 855 Oak Grove Avenue Suite 100 Menlo Park CA 94025 6506067910 Arjun Agarwal Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

533 50613.68 66209699 09/21/2026 NASDAQ Common 09/14/2026 Restricted Stock Units Issuer N 533 09/14/2026 N/A N ARJUN AGARWAL

855 Oak Grove Avenue Suite 100 Menlo Park CA 94025

Common 09/15/2026 560 53597.60 10b5-1 Sales for ARJUN AGARWAL

855 Oak Grove Avenue Suite 100 Menlo Park CA 94025

Common 09/11/2026 9459 872413.00 10b5-1 Sales for ARJUN AGARWAL

855 Oak Grove Avenue Suite 100 Menlo Park CA 94025

Common 08/13/2026 10000 1066571.87 10b5-1 Sales for ARJUN AGARWAL

855 Oak Grove Avenue Suite 100 Menlo Park CA 94025

Common 07/13/2026 9999 846180.51 10b5-1 Sales for ARJUN AGARWAL

855 Oak Grove Avenue Suite 100 Menlo Park CA 94025

Common 06/22/2026 1587 128468.24 09/21/2026 02/11/2026 /s/ Arjun Agarwal