144 0002033974 XXXXXXXX LIVE 0000907654 Oruka Therapeutics, Inc. 000-22873 855 Oak Grove Avenue Suite 100 Menlo Park CA 94025 6506067910 ARJUN AGARWAL Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

22206 1375217.58 60312101 05/18/2026 NASDAQ Common 05/18/2026 Exercise of Stock Options Issuer N 19749 05/18/2026 Cash Common 12/08/2025 Employee Stock Purchase Plan Issuer N 1758 12/08/2025 Cash Common 03/14/2026 Restricted Stock Units Issuer N 699 03/14/2026 N/A N ARJUN AGARWAL

855 Oak Grove Avenue Suite 100 Menlo Park CA 94025

Common 03/16/2026 395 16313.50 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 05/18/2026 02/11/2026 /s/ Arjun Kumar Agarwal