EXHIBIT 21

ST. JUDE MEDICAL, INC.

SUBSIDIARIES OF THE REGISTRANT

as of December 29, 2012

St. Jude Medical, Inc. Wholly Owned Subsidiaries:

• Pacesetter, Inc. - Sylmar, California; Scottsdale, Arizona; and Maven, South Carolina (Delaware corporation) (dba St. Jude Medical Cardiac Rhythm Management Division)

• St. Jude Medical S.C., Inc. - Austin, Texas (Minnesota corporation)

◦ AGA Medical LLC (Minnesota limited liability company)

• St. Jude Medical Europe, Inc. - St. Paul, Minnesota (Delaware corporation)

• St. Jude Medical Canada, Inc. - Mississauga, Ontario (Ontario, Canada corporation)

• St. Jude Medical (Shanghai) Co., Ltd. - Shanghai, China (Chinese corporation)

◦ Beijing, Shanghai and Guangzhou representative offices

• St. Jude Medical Australia Pty., Ltd. - Sydney, Australia (Australian corporation) (67.11% (1,438,624 shares) held by St. Jude Medical, Inc. and 32.89% (705,000 shares) held by St. Jude Medical Asia Pacific Holdings GK)

• St. Jude Medical Brasil, Ltda. - Sao Paulo and Belo Horizonte, Brazil (Brazilian corporation)

• St. Jude Medical, Atrial Fibrillation Division, Inc. (Formerly St. Jude Medical, Daig Division, Inc.) - Minnesota and California (Minnesota corporation)

◦ Endocardial Solutions NV/SA (Belgian corporation)

◦ EP MedSystems France (French corporation)

• St. Jude Medical Colombia, Ltda. - Bogota, Colombia (Colombian corporation)

• Eagle Merger Corporation - (Delaware corporation)

• Nantucket Subsidiary Corporation - (Delaware corporation)

• St. Jude Medical ATG, Inc. - Maple Grove, Minnesota (Minnesota corporation) (Shell)

• Irvine Biomedical, Inc. - Irvine, California (California corporation)

• St. Jude Medical, Cardiology Division, Inc. (Formerly Velocimed, Inc.) - Minnesota (Delaware corporation) (dba St. Jude Medical Cardiovascular Division)

◦ LightLab Imaging, Inc. - Westford, Massachusetts (Delaware corporation)

▪ LightLab Imaging Europe B.V. (Dutch corporation)

◦ Sealing Solutions, Inc. - Plymouth, Minnesota (Georgia corporation)

• SJ Medical Mexico, S. de R.L. de C.V. - (Mexican corporation)

• St. Jude Medical Argentina S.A. - Buenos Aires, Argentina (Argentinean corporation)

• Advanced Neuromodulation Systems, Inc. - Plano, Texas (Texas corporation) (dba St. Jude Medical Neuromodulation Division)

◦ Hi-Tronics Designs, Inc. - Budd Lake, New Jersey (New Jersey corporation)

• AGA Medical Holdings, Inc. - Plymouth, Minnesota (Delaware corporation)

◦ AGA Medical Corporation - Plymouth, Minnesota (Minnesota corporation)

▪ AGA Medical Belgium SPRL (Belgian corporation)

• SJM International, Inc. - St. Paul, Minnesota (Delaware corporation)

SJM International, Inc. Wholly Owned Legal Entities (Directly and Indirectly):

• St. Jude Medical Luxembourg Holding II S.a r.l. (Luxembourg corporation)

◦ SJM Delaware Holding, LLC - St. Paul, Minnesota (Delaware limited liability company)

◦ St. Jude Medical Bermuda GP (Bermuda partnership) (SJM International, Inc. is the majority partner and SJM Delaware Holding LLC is the minority partner)

▪ St. Jude Medical Luxembourg Holding S.à r.l. (Luxembourg corporation)

• St. Jude Medical Luxembourg S.a r.l. (Luxembourg corporation)

◦ U.S. Branch of St. Jude Medical Luxembourg Holding S.à r.l.

▪ MediGuide, LLC (Delaware limited liability company)

• MediGuide Ltd. (Israeli corporation)

◦ St. Jude Medical Nederland B.V. (Netherlands corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg Holding S.à r.l.)

◦ St. Jude Medical Puerto Rico LLC (Puerto Rican corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg Holding S.à r.l.)

◦ SJM Coordination Center BVBA (Belgian corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg Holding S.à r.l.)

▪ Cardio Life Research S.A. (Belgian corporation)

▪ St. Jude Medical Balkan d.o.o. (Serbian corporation)

▪ St. Jude Medical Estonia OÜ (Estonian corporation)

▪ SJM Hellas Limited Liability Trading Company (Greece corporation)

◦ St. Jude Medical Operations (Malaysia) Sdn. Bhd. (Malaysian corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg Holding S.à r.l.)

◦ St. Jude Medical Costa Rica Limitada (Costa Rica corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg Holding S.à r.l.)

◦ St. Jude Medical Holdings B.V. (Netherlands corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg S.à r.l.)

▪ St. Jude Medical India Private Limited (Indian corporation) (wholly owned subsidiary of St. Jude Medical Holdings B.V.)

▪ St. Jude Medical New Zealand Limited (New Zealand corporation) (wholly owned subsidiary of St. Jude Medical Holdings B.V.)

▪ St. Jude Medical Asia Pacific Holdings GK (Japanese corporation) (wholly owned subsidiary of St. Jude Medical Holdings B.V.)

• St. Jude Medical Japan Co., Ltd. (Japanese corporation) (wholly owned subsidiary of St. Jude Medical Asia Pacific Holdings GK)

• St. Jude Medical (Singapore) Pte. Ltd. (Singaporean corporation) (wholly owned subsidiary of St. Jude Medical Asia Pacific Holdings GK)

• St. Jude Medical (Malaysia) Sdn Bhd (Malaysian corporation) (wholly owned subsidiary of St. Jude Medical Asia Pacific Holdings GK)

• St. Jude Medical Taiwan Co. (Taiwan corporation) (wholly owned subsidiary of St. Jude Medical Asia Pacific Holdings GK)

• St. Jude Medical Korea YH (Korean corporation) (wholly owned subsidiary of St. Jude Medical Asia Pacific Holdings GK)

• St. Jude Medical (Hong Kong) Limited (Hong Kong corporation) (wholly owned subsidiary of St. Jude Medical Asia Pacific Holdings GK)

• St. Jude Medical (Thailand) Co., Ltd. - Bangkok, Thailand (Thai corporation) (wholly owned subsidiary of St. Jude Medical Asia Pacific Holdings GK)

▪ St. Jude Medical Sweden AB (Swedish corporation)

• St. Jude Medical Systems AB (formerly Radi Medical Systems AB) (Swedish corporation)

◦ Radi Medical Systems Co., Ltd. (Thai corporation)

◦ Radi Medical Systems Pte., Ltd. (Singapore corporation)

• HB Betakonsult (Swedish partnership) (St. Jude Medical AB holds a 99% interest and St. Jude Medical Systems AB holds a 1% interest)

• St. Jude Medical Danmark A/S (Danish corporation)

• St. Jude Medical (Portugal) - Distribuição de Produtos Médicos, Lda. (Portuguese corporation)

• St. Jude Medical Export Ges.m.b.H. (Austrian corporation)

• St. Jude Medical Medizintechnik Ges.m.b.H. (Austrian corporation)

• St. Jude Medical Italia S.p.A. (Italian corporation)

• St. Jude Medical Belgium (Belgian corporation)

• St. Jude Medical España S.A. (Spanish corporation)

• St. Jude Medical France S.A.S. (French corporation)

• St. Jude Medical Finland O/y (Finnish corporation)

• St. Jude Medical Sp.zo.o. (Polish corporation)

• St. Jude Medical GmbH (German corporation)

• St. Jude Medical Kft (Hungarian corporation)

• St. Jude Medical UK Limited (United Kingdom corporation)

◦ AGA Medical Limited (United Kingdom corporation)

• St. Jude Medical (Schweiz) AG (Swiss corporation)

• UAB “St. Jude Medical Baltic” (Lithuanian corporation)

• St. Jude Medical Norway AS (Norwegian corporation)