<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0002026548</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001921865</own:issuerCik>
      <own:issuerName>ASP Isotopes, Inc.</own:issuerName>
      <own:secFileNumber>001-41555</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>2200 Ross Avenue, Suite 4575E</com:street1>
        <com:city>Dallas</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>75201</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>214-432-8219</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Heather Kiessling</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Officer</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>J.P. Morgan Securities LLC</own:name>
        <own:address>
          <com:street1>270 Park Avenue, 10th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>46248</own:noOfUnitsSold>
      <own:aggregateMarketValue>231240</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>125903447</own:noOfUnitsOutstanding>
      <own:approxSaleDate>04/15/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NASDAQ</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>04/14/2026</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Award</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>23124</own:amountOfSecuritiesAcquired>
      <own:paymentDate>04/14/2026</own:paymentDate>
      <own:natureOfPayment>N/A</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>04/15/2026</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Award</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>23124</own:amountOfSecuritiesAcquired>
      <own:paymentDate>04/15/2026</own:paymentDate>
      <own:natureOfPayment>N/A</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:remarks>Represents sale of shares to satisfy tax withholding obligations incident to the vesting of an award of restricted stock at the rate identified by the Seller as her expected effective tax rate. Of the shares filed today, 23,124 shares are Restricted Stock that will vest within three months from the date of this filing.</own:remarks>
    <own:noticeSignature>
      <own:noticeDate>04/15/2026</own:noticeDate>
      <own:planAdoptionDates>
        <own:planAdoptionDate>12/19/2025</own:planAdoptionDate>
      </own:planAdoptionDates>
      <own:signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Heather Kiessling</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
