The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109   5,232,374 24,058 SH   SOLE   24,058 0 0
ABIVAX SA SPONSORED ADS 00370M103   8,217,262 75,944 SH   SOLE   75,944 0 0
ABIVAX SA SPONSORED ADS 00370M103   11,135,000 100,000 SH Put SOLE   100,000 0 0
ABIVAX SA SPONSORED ADS 00370M103   11,135,000 100,000 SH Call SOLE   100,000 0 0
ALKERMES PLC SHS G01767105   1,768,000 50,000 SH   SOLE   50,000 0 0
ALUMIS INC COM 022307102   687,336 31,200 SH Put SOLE   31,200 0 0
ALUMIS INC COM 022307102   2,203,000 100,000 SH Call SOLE   100,000 0 0
ANAVEX LIFE SCIENCES CORP COM NEW 032797300   1,466,232 477,600 SH Call SOLE   477,600 0 0
ANNEXON INC COM 03589W102   1,956,728 353,200 SH Call SOLE   353,200 0 0
ANNEXON INC COM 03589W102   736,355 132,916 SH   SOLE   132,916 0 0
APOGEE THERAPEUTICS INC COM 03770N101   18,727,825 222,500 SH Call SOLE   222,500 0 0
ARCUS BIOSCIENCES INC COM 03969F109   5,143,867 238,142 SH   SOLE   238,142 0 0
ATRIUM THERAPEUTICS INC COM 04965N104   33,585 2,512 SH   SOLE   2,512 0 0
ATYR PHARMA INC COM NEW 002120202   9,516 12,200 SH Call SOLE   12,200 0 0
ATYR PHARMA INC COM NEW 002120202   9,750 12,500 SH Put SOLE   12,500 0 0
AYTU BIOPHARMA INC COM 054754858   963,900 353,077 SH   SOLE   353,077 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   2,210,607 476,424 SH   SOLE   476,424 0 0
BIOAGE LABS INC COM 09077V100   1,049,400 60,000 SH   SOLE   60,000 0 0
BIOHAVEN LTD COM G1110E107   2,681,820 317,000 SH Call SOLE   317,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   8,373,456 148,229 SH   SOLE   148,229 0 0
BRIDGEBIO PHARMA INC COM 10806X102   6,335,195 85,311 SH   SOLE   85,311 0 0
BRIDGEBIO PHARMA INC NOTE 1.750% 3/0 10806XAJ1   18,565,000 250,000 SH   SOLE   250,000 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309   10,010,720 329,300 SH Call SOLE   329,300 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309   18,951,360 623,400 SH Put SOLE   623,400 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309   2,397,070 78,851 SH   SOLE   78,851 0 0
CELCUITY INC COM 15102K100   2,020,278 17,700 SH Call SOLE   17,700 0 0
CELCUITY INC COM 15102K100   606,540 5,314 SH   SOLE   5,314 0 0
CLIMB BIO INC COM 28658R106   1,959,963 286,126 SH   SOLE   286,126 0 0
COGENT BIOSCIENCES INC COM 19240Q201   12,423,186 322,764 SH   SOLE   322,764 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   176,324 31,885 SH   SOLE   31,885 0 0
CONNECT BIOPHARMA HLDGS LTD SHS G23549101   525,808 200,690 SH   SOLE   200,690 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301   1,082,667 115,300 SH Call SOLE   115,300 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301   4,131,196 439,957 SH   SOLE   439,957 0 0
CORCEPT THERAPEUTICS INC COM 218352102   403,100 10,000 SH   SOLE   10,000 0 0
CORCEPT THERAPEUTICS INC COM 218352102   6,389,135 158,500 SH Call SOLE   158,500 0 0
CORMEDIX INC COM 21900C308   1,137,325 167,500 SH Put SOLE   167,500 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   3,581,585 244,811 SH   SOLE   244,811 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   1,555,169 106,300 SH Call SOLE   106,300 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   5,056,691 106,300 SH Call SOLE   106,300 0 0
CUE BIOPHARMA INC COM 22978P106   30,346 131,997 SH   SOLE   131,997 0 0
CYTOKINETICS INC COM NEW 23282W605   3,295,500 50,000 SH Call SOLE   50,000 0 0
CYTOKINETICS INC COM NEW 23282W605   13,182,000 200,000 SH Put SOLE   200,000 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105   1,485,200 316,000 SH Call SOLE   316,000 0 0
DIANTHUS THERAPEUTICS INC COM 252828108   839,200 10,000 SH   SOLE   10,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   6,693,750 212,500 SH Call SOLE   212,500 0 0
ELI LILLY & CO COM 532457108   5,518,620 6,000 SH   SOLE   6,000 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106   820,344 64,952 SH   SOLE   64,952 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102   9,604 245 SH   SOLE   245 0 0
ENTERA BIO LTD SHS M40527109   25,819 23,260 SH   SOLE   23,260 0 0
EQUILLIUM INC COM 29446K106   867,688 433,844 SH   SOLE   433,844 0 0
EUPRAXIA PHARMACEUTICALS INC COM 29842P105   289,600 40,000 SH   SOLE   40,000 0 0
EVOLUS INC COM 30052C107   514,572 125,200 SH Call SOLE   125,200 0 0
EYEPOINT INC COM NEW 30233G209   1,370,207 106,300 SH Call SOLE   106,300 0 0
EYEPOINT INC COM NEW 30233G209   2,301,445 178,545 SH   SOLE   178,545 0 0
FOGHORN THERAPEUTICS INC COM 344174107   382,132 79,944 SH   SOLE   79,944 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   377,314 26,836 SH   SOLE   26,836 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   2,601,121 92,864 SH   SOLE   92,864 0 0
IMMUNITYBIO INC COM 45256X103   815,321 106,300 SH Put SOLE   106,300 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105   5,824,648 193,189 SH   SOLE   193,189 0 0
INCYTE CORP COM 45337C102   9,920,248 105,400 SH Put SOLE   105,400 0 0
INCYTE CORP COM 45337C102   7,344,089 78,029 SH   SOLE   78,029 0 0
INDIVIOR PHARMACEUTICALS INC COM 45579U109   2,175,540 71,376 SH   SOLE   71,376 0 0
INOVIO PHARMACEUTICALS INC COM SHS 45773H409   130,848 75,200 SH Call SOLE   75,200 0 0
INOVIO PHARMACEUTICALS INC COM SHS 45773H409   979,037 562,665 SH   SOLE   562,665 0 0
INTELLIA THERAPEUTICS INC COM 45826J105   2,564,000 200,000 SH Call SOLE   200,000 0 0
INVENTIVA SA ADS 46124U107   1,935,023 352,399 SH   SOLE   352,399 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   10,179 2,900 SH Put SOLE   2,900 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   1,053,000 300,000 SH Call SOLE   300,000 0 0
JADE BIOSCIENCES INC COM NEW 008064206   2,930 1,046 SH Put SOLE   1,046 0 0
JANUX THERAPEUTICS INC COM 47103J105   439,240 31,600 SH Call SOLE   31,600 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   10,351,433 54,755 SH   SOLE   54,755 0 0
JOHNSON & JOHNSON COM 478160104   13,143,783 53,771 SH   SOLE   53,771 0 0
KARYOPHARM THERAPEUTICS INC COM NEW 48576U205   1,344,041 241,300 SH Call SOLE   241,300 0 0
KODIAK SCIENCES INC COM 50015M109   9,411,828 246,900 SH Put SOLE   246,900 0 0
KODIAK SCIENCES INC COM 50015M109   7,355,711 192,962 SH   SOLE   192,962 0 0
KODIAK SCIENCES INC COM 50015M109   7,624 200 SH Call SOLE   200 0 0
LARIMAR THERAPEUTICS INC COM 517125100   749,867 166,637 SH   SOLE   166,637 0 0
LIPOCINE INC NEW COM NEW 53630X203   399,500 50,000 SH   SOLE   50,000 0 0
LIQUIDIA CORPORATION COM NEW 53635D202   24,987,654 662,100 SH Call SOLE   662,100 0 0
LIQUIDIA CORPORATION COM NEW 53635D202   1,887,000 50,000 SH Put SOLE   50,000 0 0
LYELL IMMUNOPHARMA INC COM NEW 55083R203   82,246 4,100 SH Put SOLE   4,100 0 0
MACROGENICS INC COM 556099109   1,734,000 600,000 SH   SOLE   600,000 0 0
MANNKIND CORP COM NEW 56400P706   457,177 186,603 SH   SOLE   186,603 0 0
MAZE THERAPEUTICS INC COM 578784100   447,750 15,000 SH   SOLE   15,000 0 0
MERCK & CO INC COM 58933Y105   12,029,000 100,000 SH Put SOLE   100,000 0 0
MINERALYS THERAPEUTICS INC COM 603170101   713,740 26,347 SH   SOLE   26,347 0 0
MODERNA INC COM 60770K107   8,097,520 159,400 SH Put SOLE   159,400 0 0
MONOPAR THERAPEUTICS INC COM NEW 61023L207   89,308 1,630 SH   SOLE   1,630 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   3,081,200 187,307 SH   SOLE   187,307 0 0
NOVO-NORDISK A S ADR 670100205   520,736 14,577 SH   SOLE   14,577 0 0
NOVO-NORDISK A S ADR 670100205   2,054,325 55,900 SH Put SOLE   55,900 0 0
OCUGEN INC COM 67577C105   362,000 200,000 SH   SOLE   200,000 0 0
OCUGEN INC COM 67577C105   543,000 300,000 SH Call SOLE   300,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106   1,252,440 84,000 SH Call SOLE   84,000 0 0
PASSAGE BIO INC COM NEW 702712209   153,311 19,530 SH   SOLE   19,530 0 0
PELTHOS THERAPEUTICS INC COM SHS 171126204   520,481 24,773 SH   SOLE   24,773 0 0
PEPGEN INC COM 713317105   267,137 150,925 SH   SOLE   150,925 0 0
PHARVARIS N V COM N69605108   828,318 29,321 SH   SOLE   29,321 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   607,162 54,650 SH   SOLE   54,650 0 0
PRECIGEN INC COM 74017N105   213,984 55,293 SH   SOLE   55,293 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109   291,734 180,083 SH   SOLE   180,083 0 0
PURETECH HEALTH PLC ADS 746237106   11,327 7,924 SH   SOLE   7,924 0 0
RELMADA THERAPEUTICS INC COM 75955J402   1,397,860 200,842 SH   SOLE   200,842 0 0
REPLIMUNE GROUP INC COM 76029N106   770,049 100,660 SH   SOLE   100,660 0 0
REPLIMUNE GROUP INC COM 76029N106   3,518,235 459,900 SH Put SOLE   459,900 0 0
REPLIMUNE GROUP INC COM 76029N106   1,572,075 205,500 SH Call SOLE   205,500 0 0
REVOLUTION MEDICINES INC COM 76155X100   7,864,802 80,872 SH   SOLE   80,872 0 0
REVOLUTION MEDICINES INC COM 76155X100   12,204,875 125,500 SH Put SOLE   125,500 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   109,473 30,579 SH   SOLE   30,579 0 0
ROIVANT SCIENCES LTD SHS G76279101   9,301,660 335,800 SH Put SOLE   335,800 0 0
SELLAS LIFE SCIENCES GROUP I COM NEW 81642T209   1,269,000 300,000 SH Call SOLE   300,000 0 0
SEPTERNA INC COM 81734D104   4,854 202 SH   SOLE   202 0 0
SHATTUCK LABS INC COM 82024L103   1,888,260 293,664 SH   SOLE   293,664 0 0
SPRUCE BIOSCIENCES INC COM NEW 85209E208   653,500 10,000 SH   SOLE   10,000 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   3,481,679 72,234 SH   SOLE   72,234 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   6,145,500 127,500 SH Put SOLE   127,500 0 0
TALPHERA INC COM NEW 00444T209   114,696 153,563 SH   SOLE   153,563 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   1,819,831 25,942 SH   SOLE   25,942 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605   2,874,011 179,738 SH   SOLE   179,738 0 0
TERNS PHARMACEUTICALS INC COM 880881107   9,581,965 181,752 SH   SOLE   181,752 0 0
TG THERAPEUTICS INC COM 88322Q108   6,874,148 206,928 SH   SOLE   206,928 0 0
TREVI THERAPEUTICS INC COM 89532M101   258,440 21,663 SH   SOLE   21,663 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   736,267 35,144 SH   SOLE   35,144 0 0
UNICYCIVE THERAPEUTICS INC COM NEW 90466Y202   698,026 106,083 SH   SOLE   106,083 0 0
UNIQURE NV SHS N90064101   4,087,500 250,000 SH Call SOLE   250,000 0 0
UNIQURE NV SHS N90064101   4,888,650 299,000 SH Put SOLE   299,000 0 0
UNIQURE NV SHS N90064101   510,120 31,200 SH   SOLE   31,200 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   11,859,600 20,000 SH Put SOLE   20,000 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   16,190,133 27,303 SH   SOLE   27,303 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   23,837,796 40,200 SH Call SOLE   40,200 0 0
UPSTREAM BIO INC COM 91678A107   194,481 21,609 SH   SOLE   21,609 0 0
UROGEN PHARMA LTD COM M96088105   416,327 23,155 SH   SOLE   23,155 0 0
VAXCYTE INC COM 92243G108   3,085,641 53,100 SH Call SOLE   53,100 0 0
VAXCYTE INC COM 92243G108   1,456,876 25,071 SH   SOLE   25,071 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   1,714,714 3,840 SH   SOLE   3,840 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   41,572,874 93,100 SH Call SOLE   93,100 0 0
VIKING THERAPEUTICS INC COM 92686J106   17,089,390 525,181 SH   SOLE   525,181 0 0
VIKING THERAPEUTICS INC COM 92686J106   21,450,368 659,200 SH Call SOLE   659,200 0 0
VIR BIOTECHNOLOGY INC COM 92764N102   795,648 88,800 SH Call SOLE   88,800 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400   60,252 105,428 SH   SOLE   105,428 0 0
VOYAGER THERAPEUTICS INC COM 92915B106   579,000 150,000 SH Call SOLE   150,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106   1,635,258 423,642 SH   SOLE   423,642 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103   769,927 132,746 SH   SOLE   132,746 0 0
ZYMEWORKS INC COM 98985Y108   3,558,985 142,132 SH   SOLE   142,132 0 0