ABBVIE INC COM 00287Y109 5232374 24058 SH SOLE 24058 0 0 ABIVAX SA SPONSORED ADS 00370M103 8217262 75944 SH SOLE 75944 0 0 ABIVAX SA SPONSORED ADS 00370M103 11135000 100000 SH Put SOLE 100000 0 0 ABIVAX SA SPONSORED ADS 00370M103 11135000 100000 SH Call SOLE 100000 0 0 ALKERMES PLC SHS G01767105 1768000 50000 SH SOLE 50000 0 0 ALUMIS INC COM 022307102 687336 31200 SH Put SOLE 31200 0 0 ALUMIS INC COM 022307102 2203000 100000 SH Call SOLE 100000 0 0 ANAVEX LIFE SCIENCES CORP COM NEW 032797300 1466232 477600 SH Call SOLE 477600 0 0 ANNEXON INC COM 03589W102 1956728 353200 SH Call SOLE 353200 0 0 ANNEXON INC COM 03589W102 736355 132916 SH SOLE 132916 0 0 APOGEE THERAPEUTICS INC COM 03770N101 18727825 222500 SH Call SOLE 222500 0 0 ARCUS BIOSCIENCES INC COM 03969F109 5143867 238142 SH SOLE 238142 0 0 ATRIUM THERAPEUTICS INC COM 04965N104 33585 2512 SH SOLE 2512 0 0 ATYR PHARMA INC COM NEW 002120202 9516 12200 SH Call SOLE 12200 0 0 ATYR PHARMA INC COM NEW 002120202 9750 12500 SH Put SOLE 12500 0 0 AYTU BIOPHARMA INC COM 054754858 963900 353077 SH SOLE 353077 0 0 BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 2210607 476424 SH SOLE 476424 0 0 BIOAGE LABS INC COM 09077V100 1049400 60000 SH SOLE 60000 0 0 BIOHAVEN LTD COM G1110E107 2681820 317000 SH Call SOLE 317000 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 8373456 148229 SH SOLE 148229 0 0 BRIDGEBIO PHARMA INC COM 10806X102 6335195 85311 SH SOLE 85311 0 0 BRIDGEBIO PHARMA INC NOTE 1.750% 3/0 10806XAJ1 18565000 250000 SH SOLE 250000 0 0 CAPRICOR THERAPEUTICS INC COM NEW 14070B309 10010720 329300 SH Call SOLE 329300 0 0 CAPRICOR THERAPEUTICS INC COM NEW 14070B309 18951360 623400 SH Put SOLE 623400 0 0 CAPRICOR THERAPEUTICS INC COM NEW 14070B309 2397070 78851 SH SOLE 78851 0 0 CELCUITY INC COM 15102K100 2020278 17700 SH Call SOLE 17700 0 0 CELCUITY INC COM 15102K100 606540 5314 SH SOLE 5314 0 0 CLIMB BIO INC COM 28658R106 1959963 286126 SH SOLE 286126 0 0 COGENT BIOSCIENCES INC COM 19240Q201 12423186 322764 SH SOLE 322764 0 0 COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 176324 31885 SH SOLE 31885 0 0 CONNECT BIOPHARMA HLDGS LTD SHS G23549101 525808 200690 SH SOLE 200690 0 0 CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 1082667 115300 SH Call SOLE 115300 0 0 CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 4131196 439957 SH SOLE 439957 0 0 CORCEPT THERAPEUTICS INC COM 218352102 403100 10000 SH SOLE 10000 0 0 CORCEPT THERAPEUTICS INC COM 218352102 6389135 158500 SH Call SOLE 158500 0 0 CORMEDIX INC COM 21900C308 1137325 167500 SH Put SOLE 167500 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 3581585 244811 SH SOLE 244811 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 1555169 106300 SH Call SOLE 106300 0 0 CRISPR THERAPEUTICS AG NAMEN AKT H17182108 5056691 106300 SH Call SOLE 106300 0 0 CUE BIOPHARMA INC COM 22978P106 30346 131997 SH SOLE 131997 0 0 CYTOKINETICS INC COM NEW 23282W605 3295500 50000 SH Call SOLE 50000 0 0 CYTOKINETICS INC COM NEW 23282W605 13182000 200000 SH Put SOLE 200000 0 0 CYTOMX THERAPEUTICS INC. COM 23284F105 1485200 316000 SH Call SOLE 316000 0 0 DIANTHUS THERAPEUTICS INC COM 252828108 839200 10000 SH SOLE 10000 0 0 EDGEWISE THERAPEUTICS INC COM 28036F105 6693750 212500 SH Call SOLE 212500 0 0 ELI LILLY & CO COM 532457108 5518620 6000 SH SOLE 6000 0 0 ENANTA PHARMACEUTICALS INC COM 29251M106 820344 64952 SH SOLE 64952 0 0 ENLIVEN THERAPEUTICS INC COM 29337E102 9604 245 SH SOLE 245 0 0 ENTERA BIO LTD SHS M40527109 25819 23260 SH SOLE 23260 0 0 EQUILLIUM INC COM 29446K106 867688 433844 SH SOLE 433844 0 0 EUPRAXIA PHARMACEUTICALS INC COM 29842P105 289600 40000 SH SOLE 40000 0 0 EVOLUS INC COM 30052C107 514572 125200 SH Call SOLE 125200 0 0 EYEPOINT INC COM NEW 30233G209 1370207 106300 SH Call SOLE 106300 0 0 EYEPOINT INC COM NEW 30233G209 2301445 178545 SH SOLE 178545 0 0 FOGHORN THERAPEUTICS INC COM 344174107 382132 79944 SH SOLE 79944 0 0 GH RESEARCH PLC ORDINARY SHARES G3855L106 377314 26836 SH SOLE 26836 0 0 HARMONY BIOSCIENCES HLDGS IN COM 413197104 2601121 92864 SH SOLE 92864 0 0 IMMUNITYBIO INC COM 45256X103 815321 106300 SH Put SOLE 106300 0 0 IMMUNOCORE HLDGS PLC ADS 45258D105 5824648 193189 SH SOLE 193189 0 0 INCYTE CORP COM 45337C102 9920248 105400 SH Put SOLE 105400 0 0 INCYTE CORP COM 45337C102 7344089 78029 SH SOLE 78029 0 0 INDIVIOR PHARMACEUTICALS INC COM 45579U109 2175540 71376 SH SOLE 71376 0 0 INOVIO PHARMACEUTICALS INC COM SHS 45773H409 130848 75200 SH Call SOLE 75200 0 0 INOVIO PHARMACEUTICALS INC COM SHS 45773H409 979037 562665 SH SOLE 562665 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 2564000 200000 SH Call SOLE 200000 0 0 INVENTIVA SA ADS 46124U107 1935023 352399 SH SOLE 352399 0 0 IOVANCE BIOTHERAPEUTICS INC COM 462260100 10179 2900 SH Put SOLE 2900 0 0 IOVANCE BIOTHERAPEUTICS INC COM 462260100 1053000 300000 SH Call SOLE 300000 0 0 JADE BIOSCIENCES INC COM NEW 008064206 2930 1046 SH Put SOLE 1046 0 0 JANUX THERAPEUTICS INC COM 47103J105 439240 31600 SH Call SOLE 31600 0 0 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 10351433 54755 SH SOLE 54755 0 0 JOHNSON & JOHNSON COM 478160104 13143783 53771 SH SOLE 53771 0 0 KARYOPHARM THERAPEUTICS INC COM NEW 48576U205 1344041 241300 SH Call SOLE 241300 0 0 KODIAK SCIENCES INC COM 50015M109 9411828 246900 SH Put SOLE 246900 0 0 KODIAK SCIENCES INC COM 50015M109 7355711 192962 SH SOLE 192962 0 0 KODIAK SCIENCES INC COM 50015M109 7624 200 SH Call SOLE 200 0 0 LARIMAR THERAPEUTICS INC COM 517125100 749867 166637 SH SOLE 166637 0 0 LIPOCINE INC NEW COM NEW 53630X203 399500 50000 SH SOLE 50000 0 0 LIQUIDIA CORPORATION COM NEW 53635D202 24987654 662100 SH Call SOLE 662100 0 0 LIQUIDIA CORPORATION COM NEW 53635D202 1887000 50000 SH Put SOLE 50000 0 0 LYELL IMMUNOPHARMA INC COM NEW 55083R203 82246 4100 SH Put SOLE 4100 0 0 MACROGENICS INC COM 556099109 1734000 600000 SH SOLE 600000 0 0 MANNKIND CORP COM NEW 56400P706 457177 186603 SH SOLE 186603 0 0 MAZE THERAPEUTICS INC COM 578784100 447750 15000 SH SOLE 15000 0 0 MERCK & CO INC COM 58933Y105 12029000 100000 SH Put SOLE 100000 0 0 MINERALYS THERAPEUTICS INC COM 603170101 713740 26347 SH SOLE 26347 0 0 MODERNA INC COM 60770K107 8097520 159400 SH Put SOLE 159400 0 0 MONOPAR THERAPEUTICS INC COM NEW 61023L207 89308 1630 SH SOLE 1630 0 0 MONTE ROSA THERAPEUTICS INC COM 61225M102 3081200 187307 SH SOLE 187307 0 0 NOVO-NORDISK A S ADR 670100205 520736 14577 SH SOLE 14577 0 0 NOVO-NORDISK A S ADR 670100205 2054325 55900 SH Put SOLE 55900 0 0 OCUGEN INC COM 67577C105 362000 200000 SH SOLE 200000 0 0 OCUGEN INC COM 67577C105 543000 300000 SH Call SOLE 300000 0 0 OLEMA PHARMACEUTICALS INC COM 68062P106 1252440 84000 SH Call SOLE 84000 0 0 PASSAGE BIO INC COM NEW 702712209 153311 19530 SH SOLE 19530 0 0 PELTHOS THERAPEUTICS INC COM SHS 171126204 520481 24773 SH SOLE 24773 0 0 PEPGEN INC COM 713317105 267137 150925 SH SOLE 150925 0 0 PHARVARIS N V COM N69605108 828318 29321 SH SOLE 29321 0 0 PHATHOM PHARMACEUTICALS INC COM 71722W107 607162 54650 SH SOLE 54650 0 0 PRECIGEN INC COM 74017N105 213984 55293 SH SOLE 55293 0 0 PROQR THRAPEUTICS N V SHS EURO N71542109 291734 180083 SH SOLE 180083 0 0 PURETECH HEALTH PLC ADS 746237106 11327 7924 SH SOLE 7924 0 0 RELMADA THERAPEUTICS INC COM 75955J402 1397860 200842 SH SOLE 200842 0 0 REPLIMUNE GROUP INC COM 76029N106 770049 100660 SH SOLE 100660 0 0 REPLIMUNE GROUP INC COM 76029N106 3518235 459900 SH Put SOLE 459900 0 0 REPLIMUNE GROUP INC COM 76029N106 1572075 205500 SH Call SOLE 205500 0 0 REVOLUTION MEDICINES INC COM 76155X100 7864802 80872 SH SOLE 80872 0 0 REVOLUTION MEDICINES INC COM 76155X100 12204875 125500 SH Put SOLE 125500 0 0 ROCKET PHARMACEUTICALS INC COM 77313F106 109473 30579 SH SOLE 30579 0 0 ROIVANT SCIENCES LTD SHS G76279101 9301660 335800 SH Put SOLE 335800 0 0 SELLAS LIFE SCIENCES GROUP I COM NEW 81642T209 1269000 300000 SH Call SOLE 300000 0 0 SEPTERNA INC COM 81734D104 4854 202 SH SOLE 202 0 0 SHATTUCK LABS INC COM 82024L103 1888260 293664 SH SOLE 293664 0 0 SPRUCE BIOSCIENCES INC COM NEW 85209E208 653500 10000 SH SOLE 10000 0 0 STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 3481679 72234 SH SOLE 72234 0 0 STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 6145500 127500 SH Put SOLE 127500 0 0 TALPHERA INC COM NEW 00444T209 114696 153563 SH SOLE 153563 0 0 TARSUS PHARMACEUTICALS INC COM 87650L103 1819831 25942 SH SOLE 25942 0 0 TENAX THERAPEUTICS INC COM NEW 88032L605 2874011 179738 SH SOLE 179738 0 0 TERNS PHARMACEUTICALS INC COM 880881107 9581965 181752 SH SOLE 181752 0 0 TG THERAPEUTICS INC COM 88322Q108 6874148 206928 SH SOLE 206928 0 0 TREVI THERAPEUTICS INC COM 89532M101 258440 21663 SH SOLE 21663 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 736267 35144 SH SOLE 35144 0 0 UNICYCIVE THERAPEUTICS INC COM NEW 90466Y202 698026 106083 SH SOLE 106083 0 0 UNIQURE NV SHS N90064101 4087500 250000 SH Call SOLE 250000 0 0 UNIQURE NV SHS N90064101 4888650 299000 SH Put SOLE 299000 0 0 UNIQURE NV SHS N90064101 510120 31200 SH SOLE 31200 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 11859600 20000 SH Put SOLE 20000 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 16190133 27303 SH SOLE 27303 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 23837796 40200 SH Call SOLE 40200 0 0 UPSTREAM BIO INC COM 91678A107 194481 21609 SH SOLE 21609 0 0 UROGEN PHARMA LTD COM M96088105 416327 23155 SH SOLE 23155 0 0 VAXCYTE INC COM 92243G108 3085641 53100 SH Call SOLE 53100 0 0 VAXCYTE INC COM 92243G108 1456876 25071 SH SOLE 25071 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 1714714 3840 SH SOLE 3840 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 41572874 93100 SH Call SOLE 93100 0 0 VIKING THERAPEUTICS INC COM 92686J106 17089390 525181 SH SOLE 525181 0 0 VIKING THERAPEUTICS INC COM 92686J106 21450368 659200 SH Call SOLE 659200 0 0 VIR BIOTECHNOLOGY INC COM 92764N102 795648 88800 SH Call SOLE 88800 0 0 VISTAGEN THERAPEUTICS INC COM 92840H400 60252 105428 SH SOLE 105428 0 0 VOYAGER THERAPEUTICS INC COM 92915B106 579000 150000 SH Call SOLE 150000 0 0 VOYAGER THERAPEUTICS INC COM 92915B106 1635258 423642 SH SOLE 423642 0 0 XERIS BIOPHARMA HOLDINGS INC COM 98422E103 769927 132746 SH SOLE 132746 0 0 ZYMEWORKS INC COM 98985Y108 3558985 142132 SH SOLE 142132 0 0