144 0002023255 XXXXXXXX LIVE 0001681087 TECTONIC THERAPEUTIC INC 001-38537 490 Arsenal Way Suite 200 Watertown MA 02472 3396663320 PETER MCNAMARA Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

129 4111.23 19549366 08/12/2026 NASDAQ Common 08/12/2026 Exercise of Stock Options Issuer N 129 08/12/2026 Cash N 10b5-1 Sales for PETER MCNAMARA

490 Arsenal Way Suite 200 Watertown MA 02472

Common 06/30/2026 172 6020.00 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 08/12/2026 11/14/2025 /s/ Peter McNamara