Exhibit 107

Calculation of Filing Fee Table

Form S-1

(Form Type)

Upstream Bio, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

	Security  Type	Security Class Title	Fee  Calculation  Rule	Maximum Aggregate Offering  Price(1)(2)	Fee Rate	Amount of  Registration  Fee
Fees to Be Paid	Equity	Common Stock, par value $0.001 per share	457(o)	$100,000,000	0.00014760	$14,760.00
	Total Offering Amounts			$100,000,000		$14,760.00
	Total Fees Previously Paid					—
	Total Fee Offsets					—
	Net Fee Due					$14,760.00

⁽¹⁾  Estimated solely for the purpose of computing the registration fee in accordance with Rule 457(o) under the Securities Act of 1933, as amended.

⁽²⁾ Includes the aggregate offering price of additional shares that the underwriters have the option to purchase.