Exhibit 3.1

REGISTERED OFFICE CERTIFICATE

OF

SILEXION THERAPEUTICS CORP

Cricket Square, Hutchins Drive

P.O. Box 2681

Grand Cayman KY1-1111

Cayman Islands

We, Conyers Trust Company (Cayman) Limited, Registered Office of Silexion Therapeutics Corp (the “Company”) DO HEREBY CERTIFY that the following is a true extract of the ordinary resolution passed at the extraordinary general meeting by the shareholders of the Companydated August 19^th 2025, and that such resolution has not been modified.

“Authorized Share Capital Increase Proposal

RESOLVED, as an ordinary resolution, that the authorized share capital of the Company be increased as follows:

from US$20,000 divided into 1,481,482 ordinary shares of a par value of US$0.0135 each,

to US$121,500 divided into 9,000,000 ordinary shares of a par value of US$0.0135 each.”

/s/ Charlotte Cloete

Charlotte Cloete

for and on behalf of

Conyers Trust Company (Cayman) Limited

Registered Office

Dated this 19^th day of August 2025