<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0002022416</cik>
        <entityName>Silexion Therapeutics Corp</entityName>
        <issuerAddress>
            <street1>12 ABBA HILLEL ROAD</street1>
            <city>RAMAT GAN</city>
            <stateOrCountry>L3</stateOrCountry>
            <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
            <zipCode>5250606</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>+972-3-756-4999</issuerPhoneNumber>
        <jurisdictionOfInc>CAYMAN ISLANDS</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>Biomotion Sciences</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2024</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ilan</firstName>
                <lastName>Hadar</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Silexion Therapeutics Corp</street1>
                <street2>12 Abba Hillel Road</street2>
                <city>Ramat Gan</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>5250606</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mirit</firstName>
                <lastName>Horenshtein-Hadar</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Silexion Therapeutics Corp</street1>
                <street2>12 Abba Hillel Road</street2>
                <city>Ramat Gan</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>5250606</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ruth</firstName>
                <lastName>Alon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Silexion Therapeutics Corp</street1>
                <street2>12 Abba Hillel Road</street2>
                <city>Ramat Gan</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>5250606</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ilan</firstName>
                <lastName>Levin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Silexion Therapeutics Corp</street1>
                <street2>12 Abba Hillel Road</street2>
                <city>Ramat Gan</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>5250606</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Avner</firstName>
                <lastName>Lushi</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Silexion Therapeutics Corp</street1>
                <street2>12 Abba Hillel Road</street2>
                <city>Ramat Gan</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>5250606</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Shlomo</firstName>
                <lastName>Noy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Silexion Therapeutics Corp</street1>
                <street2>12 Abba Hillel Road</street2>
                <city>Ramat Gan</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>5250606</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Amnon</firstName>
                <lastName>Peled</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Silexion Therapeutics Corp</street1>
                <street2>12 Abba Hillel Road</street2>
                <city>Ramat Gan</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>5250606</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dror</firstName>
                <lastName>Abramov</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Silexion Therapeutics Corp</street1>
                <street2>12 Abba Hillel Road</street2>
                <city>Ramat Gan</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>5250606</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mitchell</firstName>
                <lastName>Shirvan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Silexion Therapeutics Corp</street1>
                <street2>12 Abba Hillel Road</street2>
                <city>Ramat Gan</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>5250606</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2025-08-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>H.C. Wainwright &amp; Co., LLC</recipientName>
                <recipientCRDNumber>000000375</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>430 Park Avenue</street1>
                    <street2>3rd Floor</street2>
                    <city>NEW YORK</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10022</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>IL</state>
                    <description>ILLINOIS</description>
                    <state>KY</state>
                    <description>KENTUCKY</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>3597662</totalOfferingAmount>
            <totalAmountSold>3597662</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Form D covers new warrants issued 8/1/2025: investor warrants (304,212 at $11.32/share) and agent warrants (10,647 at $14.4625/share). Excludes exercise of warrants issued Jan 2025. Total offering amount equals exercise price of new warrants.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>11</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>140789</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>909500</dollarAmount>
            </findersFees>
            <clarificationOfResponse>7% cash fee + 1% mgmt. fee to H.C. Wainwright on warrant exercise proceeds. Finder's fees: $25,000 expense allowance, $50,000 legal/out-of-pocket expenses, &amp; $15,950 clearing fees. HCW agent warrants instead included in Item 13.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>Silexion Therapeutics Corp expects to use any proceeds from the future exercise of the new warrants for general corporate purposes. No proceeds are expected to be paid to executive officers, directors, or promoters.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Silexion Therapeutics Corp</issuerName>
                <signatureName>/s/ Ilan Hadar</signatureName>
                <nameOfSigner>Ilan Hadar</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2025-08-11</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
