Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Silexion Therapeutics Corp of our report dated March 18, 2025 relating to the financial statements, which appears in Silexion Therapeutics Corp’s Annual Report on Form 10-K for the year ended December 31, 2024.

Tel-Aviv, Israel	/s/ Kesselman & Kesselman
March 18, 2025	Certified Public Accountants (Isr.)
	A member firm of PricewaterhouseCoopers International Limited