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Condensed Consolidated Balance Sheet and Statement of Operations and Comprehensive Loss Components
 9 Months Ended
Sep. 30, 2025
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Condensed Consolidated Balance Sheet and Statement of Operations and Comprehensive Loss Components Condensed Consolidated Balance Sheet and Statement of Operations and Comprehensive Loss Components
Prepaid Expenses and Other Current Assets
Prepaid expenses and other current assets consist of the following:
As of September 30, 2025As of December 31, 2024
(amounts in thousands)
Prepaid expenses$18,657 $13,562 
Other current assets2,577 6,708 
Total prepaid expenses and other current assets$21,234 $20,270 
Property and Equipment, Net
Property and equipment, net consist of the following:
As of September 30, 2025As of December 31, 2024
(amounts in thousands)
Computer equipment and software$75,814 $73,312 
Capitalized software27,097 25,921 
Laboratory equipment108,476 103,795 
Furniture and fixtures8,305 9,110 
Leasehold improvements/Leased buildings63,502 63,039 
Aircraft and leased equipment21,255 21,249 
Total property and equipment304,449 296,426 
Less: accumulated depreciation and amortization(240,452)(228,609)
Property and equipment, net$63,997 $67,817 
Total depreciation and amortization expense was $4.9 million and $10.5 million for the three months ended September 30, 2025 and 2024, respectively, and $18.3 million and $39.8 million for the nine months ended September 30, 2025 and 2024, respectively.
Accrued Expenses and Other Current Liabilities
Accrued expenses and other current liabilities consist of the following:
As of September 30, 2025As of December 31, 2024
(amounts in thousands)
Trade accruals$5,635 $7,131 
Accrued payroll and employee medical14,270 17,882 
Accrued bonus20,905 25,736 
Current portion of early exercise stock option liability327 4,957 
Contract liability2,791 7,470 
Current portion of operating lease liabilities6,450 6,080 
Other accrued expenses6,489 8,286 
Total accrued expenses and other current liabilities$56,867 $77,542 
Other Long-Term Liabilities
Other long-term liabilities consist of the following:
As of September 30, 2025As of December 31, 2024
(amounts in thousands)
Long-term operating lease liabilities, net of current portion $43,828 $38,651 
Long-term portion of early exercise stock option liability53 5,767 
Total other long-term liabilities$43,881 $44,418 
Other Income (Expense), Net
Other income (expense), net, consists of the following:
Three Months Ended September 30,Nine Months Ended September 30,
2025202420252024
(amounts in thousands)
Loss on debt extinguishment$— $— $(17,930)$— 
Other(89)37 (517)(323)
Total other income (expense), net$(89)$37 $(18,447)$(323)