X0202 SCHEDULE 13G/A 0001677508 XXXXXXXX LIVE 2 Common Stock, par value $0.001 per share 03/31/2026 0002019410 CARIS LIFE SCIENCES, INC. 142152107 750 W. John Carpenter Freeway, Suite 800 Irving TX 75039 Rule 13d-1(d) TSSP Sub-Fund HoldCo, LLC DE 0.00 13666128.00 0.00 13666128.00 13666128.00 N 4.8 OO Alan Waxman X1 0.00 14385399.00 0.00 14385399.00 14385399.00 N 5.1 IN HC CARIS LIFE SCIENCES, INC. 750 W. John Carpenter Freeway, Suite 800 Irving, TX 75039 This Amendment No. 2 to Schedule 13G is being filed jointly by TSSP Sub-Fund HoldCo, LLC ("Sub-Fund Holdco") and Alan Waxman ("Mr. Waxman" and each a "Reporting Person" and, together, the "Reporting Persons"), pursuant to an Agreement of Joint Filing incorporated by reference herein in accordance with Rule 13d-1(k)(1) under the Act. The principal business address of Sub-Fund HoldCo is as follows: c/o Sixth Street Partners, LLC 2100 McKinney Avenue Suite 1500 Dallas, TX 75201 The principal business address of Mr. Waxman is as follows: 1 Letterman Drive, Building B, Suite B6-100 San Francisco, CA 94129 Sub-Fund HoldCo is organized under the laws of the State of Delaware. Mr. Waxman is a citizen of the United States. Y As of March 31, 2026, each of the Reporting Persons may be deemed to be the beneficial owner of the common stock, par value $0.001 per share ("Common Stock") listed on such Reporting Person's cover page. Calculation of the percentage of Common Stock beneficially owned as of March 31, 2026 is based on 282,579,919 shares of Common Stock outstanding as of February 26, 2026 as disclosed in the Issuer's Annual Report filed on Form 10-K filed with the Securities and Exchange Commission on March 3, 2026. As of March 31, 2026, 3,354,972 shares of Common Stock are held directly by Barnett Equity Holdings, LLC, 719,271 shares of Common Stock are held directly by Sixth Street Specialty Lending Inc., 2,290,056 shares of Common Stock are held directly by TOP III Barnett Investments, LLC, 5,960,051 shares of Common Stock are held directly by Barnett Equity Holdings II, LLC and 2,061,049 shares of Common Stock are held directly by TAO Barnett Investments, LLC. TAO SPV GP, LLC, a Delaware limited liability company, is the managing member of each of (i) Barnett Equity Holdings, LLC; (ii) Barnett Equity Holdings II LLC; and (iii) TAO Barnett Investments, LLC. Empire SPV GP, LLC, a Delaware limited liability company, is the managing member of TOP III Barnett Investments, LLC. Sub-Fund HoldCo is the sole member of each of TAO SPV GP, LLC and Empire SPV GP, LLC. Sixth Street Specialty Lending, Inc. is managed by Sixth Street Specialty Lending Advisers, LLC, a Delaware limited liability company. TSSP Holdco Management, LLC, a Delaware limited liability company ("Holdco Management"), manages Sixth Street Specialty Lending Advisers Holdings, LLC, a Delaware limited liability company. The business and affairs of Sixth Street Specialty Lending Advisers, LLC are managed by Sixth Street Specialty Lending Advisers Holdings, LLC, the sole member of Sixth Street Specialty Lending Advisers, LLC. Sub-Fund HoldCo is managed by its sole member, whose managing member is Mr. Waxman. Holdco Management is managed by a board of directors, which is currently comprised of Mr. Waxman. Mr. Waxman is the CEO of Holdco Management. Each Reporting Person disclaims beneficial ownership of the securities held directly by Barnett Equity Holdings, LLC, Sixth Street Specialty Lending Inc, TOP III Barnett Investments, LLC, Barnett Equity Holdings II, LLC and TAO Barnett Investments, LLC. Neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that any Reporting Person is the beneficial owner of the Common Stock referred to herein for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose. See each cover page hereof. See each cover page hereof. See each cover page hereof. See each cover page hereof. See each cover page hereof. N Y Y Y Y Y Exhibit 1 - Agreement of Joint Filing (previously filed) Exhibit 2 - Authorization and Designation Letter, dated December 31, 2024, by Alan Waxman (previously filed) TSSP Sub-Fund HoldCo, LLC /s/ Joshua Peck 05/12/2026 Alan Waxman /s/ Joshua Peck 05/12/2026 Joshua Peck is signing on behalf of Mr. Waxman pursuant to an authorization and designation letter dated December 31, 2024.