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<ACCEPTANCE-DATETIME>20250609070515
ACCESSION NUMBER:		0001104659-25-057593
CONFORMED SUBMISSION TYPE:	S-1/A
PUBLIC DOCUMENT COUNT:		53
FILED AS OF DATE:		20250609
DATE AS OF CHANGE:		20250609

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Caris Life Sciences, Inc.
		CENTRAL INDEX KEY:			0002019410
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				852077369
		STATE OF INCORPORATION:			TX
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-287551
		FILM NUMBER:		251032807

	BUSINESS ADDRESS:	
		STREET 1:		750 W JOHN CARPENTER FREEWAY
		STREET 2:		SUITE 800
		CITY:			IRVING
		STATE:			TX
		ZIP:			75039
		BUSINESS PHONE:		(866) 771-8946

	MAIL ADDRESS:	
		STREET 1:		750 W JOHN CARPENTER FREEWAY
		STREET 2:		SUITE 800
		CITY:			IRVING
		STATE:			TX
		ZIP:			75039
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<FILENAME>tm2415719-16_s1a.htm
<DESCRIPTION>S-1/A
<TEXT>
Document 1 - file: tm2415719-16_s1a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.1
<SEQUENCE>2
<FILENAME>tm2415719d17_ex1-1.htm
<DESCRIPTION>EXHIBIT 1.1
<TEXT>
Document 2 - file: tm2415719d17_ex1-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-3.1
<SEQUENCE>3
<FILENAME>tm2415719d17_ex3-1.htm
<DESCRIPTION>EXHIBIT 3.1
<TEXT>
Document 3 - file: tm2415719d17_ex3-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-3.2
<SEQUENCE>4
<FILENAME>tm2415719d17_ex3-2.htm
<DESCRIPTION>EXHIBIT 3.2
<TEXT>
Document 4 - file: tm2415719d17_ex3-2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-3.4
<SEQUENCE>5
<FILENAME>tm2415719d17_ex3-4.htm
<DESCRIPTION>EXHIBIT 3.4
<TEXT>
Document 5 - file: tm2415719d17_ex3-4.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.1
<SEQUENCE>6
<FILENAME>tm2415719d17_ex4-1.htm
<DESCRIPTION>EXHIBIT 4.1
<TEXT>
Document 6 - file: tm2415719d17_ex4-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>7
<FILENAME>tm2415719d17_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 7 - file: tm2415719d17_ex5-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.4(A)
<SEQUENCE>8
<FILENAME>tm2415719d17_ex10-4a.htm
<DESCRIPTION>EXHIBIT 10.4(A)
<TEXT>
Document 8 - file: tm2415719d17_ex10-4a.htm

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<DOCUMENT>
<TYPE>EX-10.5(A)
<SEQUENCE>9
<FILENAME>tm2415719d17_ex10-5a.htm
<DESCRIPTION>EXHIBIT 10.5(A)
<TEXT>
Document 9 - file: tm2415719d17_ex10-5a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.5(B)
<SEQUENCE>10
<FILENAME>tm2415719d17_ex10-5b.htm
<DESCRIPTION>EXHIBIT 10.5(B)
<TEXT>
Document 10 - file: tm2415719d17_ex10-5b.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.6
<SEQUENCE>11
<FILENAME>tm2415719d17_ex10-6.htm
<DESCRIPTION>EXHIBIT 10.6
<TEXT>
Document 11 - file: tm2415719d17_ex10-6.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-21.1
<SEQUENCE>12
<FILENAME>tm2415719d17_ex21-1.htm
<DESCRIPTION>EXHIBIT 21.1
<TEXT>
Document 12 - file: tm2415719d17_ex21-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>13
<FILENAME>tm2415719d17_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 13 - file: tm2415719d17_ex23-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>14
<FILENAME>tm2415719d17_ex23-2.htm
<DESCRIPTION>EXHIBIT 23.2
<TEXT>
Document 14 - file: tm2415719d17_ex23-2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>15
<FILENAME>tm2415719d17_ex-filingfees.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
Document 15 - file: tm2415719d17_ex-filingfees.htm

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<SEQUENCE>16
<FILENAME>lg_carislifesciences-pn.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 16 - file: lg_carislifesciences-pn.jpg

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<TEXT>
Document 17 - file: pg_carislifesciences-4c.jpg

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<FILENAME>pg_bynumbers-4c.jpg
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<TEXT>
Document 18 - file: pg_bynumbers-4c.jpg

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<SEQUENCE>19
<FILENAME>pg_casevaluegrowth-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 19 - file: pg_casevaluegrowth-4c.jpg

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<SEQUENCE>20
<FILENAME>pg_revenuegrowth-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 20 - file: pg_revenuegrowth-4c.jpg

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<FILENAME>pc_platform-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 21 - file: pc_platform-4c.jpg

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<DESCRIPTION>GRAPHIC
<TEXT>
Document 22 - file: fc_clinicalmole-4c.jpg

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<SEQUENCE>23
<FILENAME>fc_keydevelop-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 23 - file: fc_keydevelop-4c.jpg

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<TEXT>
Document 24 - file: bc_casevolume-4c.jpg

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<SEQUENCE>25
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<DESCRIPTION>GRAPHIC
<TEXT>
Document 25 - file: fc_centraldogma-4c.jpg

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Document 26 - file: tb_panels-4c.jpg

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<SEQUENCE>27
<FILENAME>pc_unique-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 27 - file: pc_unique-4c.jpg

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<SEQUENCE>28
<FILENAME>pc_unlocking-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 28 - file: pc_unlocking-4c.jpg

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Document 29 - file: pc_strategic-4c.jpg

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<SEQUENCE>30
<FILENAME>lc_oursolutions-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 30 - file: lc_oursolutions-4c.jpg

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<SEQUENCE>31
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<DESCRIPTION>GRAPHIC
<TEXT>
Document 31 - file: fc_abcdaiassure-4c.jpg

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<DOCUMENT>
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<SEQUENCE>32
<FILENAME>bc_caris-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 32 - file: bc_caris-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>33
<FILENAME>lc_significant-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 33 - file: lc_significant-4c.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>34
<FILENAME>lc_colorectal-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 34 - file: lc_colorectal-4c.jpg

</DOCUMENT>
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<TYPE>GRAPHIC
<SEQUENCE>35
<FILENAME>lc_plasmabuffy-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 35 - file: lc_plasmabuffy-4c.jpg

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<SEQUENCE>36
<FILENAME>fc_miprofile02-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 36 - file: fc_miprofile02-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>37
<FILENAME>tb_technical-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 37 - file: tb_technical-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>38
<FILENAME>bc_novelcircul-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 38 - file: bc_novelcircul-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>39
<FILENAME>fc_miprofile-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 39 - file: fc_miprofile-4c.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>40
<FILENAME>fc_companion-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 40 - file: fc_companion-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>41
<FILENAME>tb_micancer-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 41 - file: tb_micancer-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>42
<FILENAME>tb_micancerseek-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 42 - file: tb_micancerseek-4c.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>43
<FILENAME>ph_cancercate-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 43 - file: ph_cancercate-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>44
<FILENAME>fc_discovery-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 44 - file: fc_discovery-4c.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>45
<FILENAME>ph_powerofbigdata-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 45 - file: ph_powerofbigdata-4c.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>46
<FILENAME>bc_carispoanet-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 46 - file: bc_carispoanet-4c.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>47
<FILENAME>lg_datacliniclogo-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 47 - file: lg_datacliniclogo-4c.jpg

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<TYPE>GRAPHIC
<SEQUENCE>48
<FILENAME>bc_publications-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 48 - file: bc_publications-4c.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>49
<FILENAME>tb_molecular-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 49 - file: tb_molecular-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>50
<FILENAME>tm2415719d17_ex5-1img002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 50 - file: tm2415719d17_ex5-1img002.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>51
<FILENAME>tm2415719d17_ex5-1img001.jpg
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<TEXT>
Document 51 - file: tm2415719d17_ex5-1img001.jpg

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<TYPE>GRAPHIC
<SEQUENCE>52
<FILENAME>tm2415719d17_ex4-1img001.jpg
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<TEXT>
Document 52 - file: tm2415719d17_ex4-1img001.jpg

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<DOCUMENT>
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<SEQUENCE>53
<FILENAME>tm2415719d17_ex4-1img002.jpg
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<TEXT>
Document 53 - file: tm2415719d17_ex4-1img002.jpg

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