<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
<schemaVersion>X0202</schemaVersion>
<headerData>
<submissionType>SCHEDULE 13G/A</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001325073</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>



</filerInfo>
</headerData>
<formData>
<coverPageHeader>
<amendmentNo>1</amendmentNo>
<securitiesClassTitle>Common Stock, par value $0.001 per share</securitiesClassTitle>
<eventDateRequiresFilingThisStatement>03/31/2026</eventDateRequiresFilingThisStatement>
<issuerInfo>
<issuerCik>0002019410</issuerCik>
<issuerName>Caris Life Sciences, Inc.</issuerName>
<issuerCusips>
<issuerCusipNumber>142152107</issuerCusipNumber>
</issuerCusips>
<issuerPrincipalExecutiveOfficeAddress>
<com:street1>750 W. John Carpenter Freeway</com:street1>
<com:street2>Suite 800</com:street2>
<com:city>Irving</com:city>
<com:stateOrCountry>TX</com:stateOrCountry>
<com:zipCode>75039</com:zipCode>
</issuerPrincipalExecutiveOfficeAddress>
</issuerInfo>
<designateRulesPursuantThisScheduleFiled>
<designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
</designateRulesPursuantThisScheduleFiled>
</coverPageHeader>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>J H Whitney VI L P</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>18256615</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>18256615</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>18256615</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>6.5</classPercent>
<typeOfReportingPerson>PN</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>J. H. Whitney Equity Partners VI, LLC</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>18256615</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>18256615</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>18256615</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>6.5</classPercent>
<typeOfReportingPerson>OO</typeOfReportingPerson>
<typeOfReportingPerson>HC</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>VIGANO PAUL R</reportingPersonName>
<citizenshipOrOrganization>X1</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>18256615</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>18256615</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>18256615</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>6.5</classPercent>
<typeOfReportingPerson>IN</typeOfReportingPerson>
<typeOfReportingPerson>HC</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>WILLIAMS ROBERT M JR</reportingPersonName>
<citizenshipOrOrganization>X1</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>18256615</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>18256615</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>18256615</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>6.5</classPercent>
<typeOfReportingPerson>IN</typeOfReportingPerson>
<typeOfReportingPerson>HC</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<items>
<item1>
<issuerName>Caris Life Sciences, Inc.</issuerName>
<issuerPrincipalExecutiveOfficeAddress>750 W. John Carpenter Freeway, Suite 800, Irving, Texas, 75039</issuerPrincipalExecutiveOfficeAddress>
</item1>
<item2>
<filingPersonName>This Statement is filed on behalf of J.H. Whitney VI, L.P., as the direct holder of the shares reported herein, J.H. Whitney Equity Partners VI, LLC, as the sole general partner of J.H. Whitney VI, L.P., and Paul R. Vigano and Robert M. Williams, Jr., as the managing members of J.H. Whitney Equity Partners VI, LLC (collectively, the "Reporting Persons").</filingPersonName>
<principalBusinessOfficeOrResidenceAddress>The address of each Reporting Person is 212 Elm Street, Suite 1, New Canaan, CT 06840.</principalBusinessOfficeOrResidenceAddress>
<citizenship>J.H. Whitney VI, L.P. is a Delaware limited partnership. J.H. Whitney Equity Partners VI, LLC is a Delaware limited liability company. Paul R. Vigano and Robert M. Williams Jr. are citizens of the United States.</citizenship>
</item2>
<item3>
<notApplicableFlag>Y</notApplicableFlag>
</item3>
<item4>
<amountBeneficiallyOwned>18,256,615</amountBeneficiallyOwned>
<classPercent>6.5%</classPercent>
<numberOfSharesPersonHas>
<solePowerOrDirectToVote>0</solePowerOrDirectToVote>
<sharedPowerOrDirectToVote>18,256,615</sharedPowerOrDirectToVote>
<solePowerOrDirectToDispose>0</solePowerOrDirectToDispose>
<sharedPowerOrDirectToDispose>18,256,615</sharedPowerOrDirectToDispose>
</numberOfSharesPersonHas>
</item4>
<item5>
<notApplicableFlag>Y</notApplicableFlag>
</item5>
<item6>
<notApplicableFlag>N</notApplicableFlag>
<ownershipMoreThan5PercentOnBehalfOfAnotherPerson>No other person has the right to receive or the power to direct the receipt of dividends from, or proceeds from the sale of, the securities owned by J.H. Whitney VI, L.P.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
</item6>
<item7>
<notApplicableFlag>Y</notApplicableFlag>
</item7>
<item8>
<notApplicableFlag>Y</notApplicableFlag>
</item8>
<item9>
<notApplicableFlag>Y</notApplicableFlag>
</item9>
<item10>
<notApplicableFlag>Y</notApplicableFlag>
</item10>
</items>
<signatureInformation>
<reportingPersonName>J H Whitney VI L P</reportingPersonName>
<signatureDetails>
<signature>/s/ Paul R. Vigano</signature>
<title>Paul R. Vigano, Managing Member of J.H. Whitney Equity Partners VI, LLC, its General Partner</title>
<date>05/12/2026</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>J. H. Whitney Equity Partners VI, LLC</reportingPersonName>
<signatureDetails>
<signature>/s/ Paul R. Vigano</signature>
<title>Paul R. Vigano, Managing Member</title>
<date>05/12/2026</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>VIGANO PAUL R</reportingPersonName>
<signatureDetails>
<signature>/s/ Paul R. Vigano</signature>
<title>Paul R. Vigano</title>
<date>05/12/2026</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>WILLIAMS ROBERT M JR</reportingPersonName>
<signatureDetails>
<signature>/s/ Robert M. Williams, Jr.</signature>
<title>Robert M. Williams, Jr.</title>
<date>05/12/2026</date>
</signatureDetails>
</signatureInformation>
</formData>
</edgarSubmission>
