144 0002018299 XXXXXXXX LIVE 0001819133 Tango Therapeutics, Inc. 001-39485 201 Brookline Ave Suite 901 Boston MA 02215 857-320-4900 Boxer Capital Management, LLC Member of group formerly owning 10% of the shares Common Stock Wedbush Securities, Inc.

1000 Wilshire Blvd 9th Floor Los Angeles CA 90017

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200 Vesey Street 5th Floor New York NY 10281

56550 292929 107417818 11/06/2024 NASDAQ Common Stock Guggenheim Securities, LLC

330 Madison Ave. 8th Floor New York NY 10017

50000 259000 107417818 11/06/2024 NASDAQ Common Stock BofA Securities, Inc.

1111 Ave of the Americas One Bryant Park New York NY 10036-6706

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1633 Broadway 41st Floor New York NY 10019

781175 4046487 107417818 11/06/2024 NASDAQ Common Stock Jefferies LLC

520 Madison Ave. 10th Floor New York NY 10022

1225400 6347572 107417818 11/06/2024 NASDAQ Common Stock Canaccord Genuity LLC

535 Madison Ave. 14th Floor New York NY 10022

350000 1813000 107417818 11/06/2024 NASDAQ Common Stock 08/17/2020 Private Financing Tango Therapeutics, Inc. N 719374 08/17/2020 Cash Common Stock 10/13/2022 Open Market Purchases Market Participant N 70000 10/13/2022 Cash Common Stock 10/06/2022 Open Market Purchases Market Participant N 70394 10/06/2022 Cash Common Stock 10/05/2022 Open Market Purchases Market Participant N 45500 10/05/2022 Cash Common Stock 04/07/2020 Private Financing Tango Therapeutics, Inc. N 2174732 04/07/2020 Cash N Boxer Capital Management, LLC

12860 El Camino Real Suite 300 San Diego CA 92130

Common Stock 10/21/2024 625000 4468750 Boxer Capital Management, LLC

12860 El Camino Real Suite 300 San Diego CA 92130

Common Stock 10/22/2024 250000 1660000 Boxer Capital Management, LLC

12860 El Camino Real, Suite 300 San Diego NY 92130

Common Stock 10/25/2024 633000 3753690 11/06/2024 /s/ Aaron I. Davis, Managing Member