X0508 4 2024-10-18 true 0001863127 Tyra Biosciences, Inc. TYRA 0002018299 Boxer Capital Management, LLC 12860 EL CAMINO REAL SUITE 300 SAN DIEGO CA 92130 true See remarks false Common Stock 2024-10-18 4 D 0 2000000 D 4448359 I See footnote Pre-Funded Warrant (right to purchase) 0.001 2024-10-18 4 A 0 2000000 A Common Stock 2000000 2705280 I See footnote On October 18, 2024, Boxer Capital, LLC ("Boxer") entered into an exchange agreement with the Issuer, pursuant to which Boxer agreed to exchange 2,000,000 shares of the Issuer's Common Stock for a pre-funded warrant to purchase up to 2,000,000 shares of Common Stock (the "Pre-Funded Warrant"). The Pre-Funded Warrant was issued on October 22, 2024. These securities are beneficially owned indirectly by Boxer Capital Management, LLC ("BCM") as the investment manager of Boxer. BCM disclaims beneficial ownership of such securities except to the extent of its pecuniary interest therein. The Pre-Funded Warrant has no expiration date and is exercisable at any time after the date of issuance. A holder of the Pre-Funded Warrant may not exercise the Pre-Funded Warrant if the holder, together with other persons whose beneficial ownership is aggregated for purposes of Section 13 or Section 16 under the Securities Exchange Act of 1934, as amended, would beneficially own more than 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise. The Reporting Person is a member of a group that formerly beneficially owned more than 10% of the outstanding shares of the Issuer's Common Stock. By: /s/ Aaron I. Davis, Managing Member, Boxer Capital Management, LLC 2024-10-22