X0206 3 2024-10-10 0 0001819133 Tango Therapeutics, Inc. TNGX 0002018299 Boxer Capital Management, LLC 12860 EL CAMINO REAL SUITE 300 SAN DIEGO CA 92130 true See remarks. Common Stock 8198642 I See footnote Prefunded Warrant 5.1499 Common Stock 2340579 I See footnote These securities are held indirectly by Boxer Capital Management, LLC ("BCM") as the investment manager of an account holding such securities. BCM disclaims beneficial ownership of such securities except to the extent of its pecuniary interest therein. The prefunded warrants have an exercise price of $0.001 per share of Common Stock and are immediately exercisable and remain exercisable until exercised in full, subject to a 9.99% beneficial ownership limitation which may be increased or decreased by the holder upon 61 days' notice to the Issuer. The Reporting Person may be deemed a member of a group that beneficially owns more than 10% of the outstanding shares of the common stock, par value $0.001 of the Issuer. BOXER CAPITAL MANAGEMENT, LLC By: Aaron I. Davis, Managing Member /s/ Aaron I. Davis 2024-10-22