X0206 3 2024-10-10 0 0001863127 Tyra Biosciences, Inc. TYRA 0002018299 Boxer Capital Management, LLC 12860 EL CAMINO REAL SUITE 300 SAN DIEGO CA 92130 true See remarks. Common Stock 6448349 I See footnote Warrant (right to purchase) 13.009 Common Stock 705280 I See footnote These securities are held indirectly by Boxer Capital Management, LLC ("BCM") as the investment manager of an account holding such securities. BCM disclaims beneficial ownership of such securities except to the extent of its pecuniary interest therein. These Warrants are exercisable immediately (subject to any applicable beneficial ownership limitation) and do not have an expiration date. As of the date of the event requiring statement, the Reporting Person may have been deemed a member of a group that beneficially owned more than 10% of the outstanding shares of the common stock, par value $0.001 of the Issuer. Dr. Siddarth Subramony, a managing director of Boxer Capital, LLC, serves as a member of the Issuer's board of directors. On the basis of the relationship between Dr. Subramony and the Reporting Person, the Reporting Person may be considered a director of the Issuer for purposes of Section 16 of the Securities Exchange Act of 1934, as amended. BOXER CAPITAL MANAGEMENT, LLC By: Aaron I. Davis, Managing Member /s/ Aaron I. Davis 2024-10-22