144 0002018299 XXXXXXXX LIVE 0001819133 Tango Therapeutics, Inc. 001-39485 201 Brookline Ave Suite 901 Boston MA 02215 857-320-4900 Boxer Capital Management, LLC Member of group owning over 10% of the shares Common Stock Jefferies LLC

520 Madison Ave. 10th Floor New York NY 10022

500000 3730000 107144465 10/21/2024 NASDAQ Common Stock BofA Securities Inc.

1111 Ave of the Americas One Bryant Park New York NY 10036-6706

125000 932500 107144465 10/21/2024 NASDAQ Common Stock 10/13/2023 Open Market Purchases Market Participant N 625000 10/13/2023 Cash Y 10/21/2024 /s/Aaron I. Davis, Managing Member