X0202 SCHEDULE 13G 0001224962 XXXXXXXX LIVE Common Stock, par value $0.0001 per share 07/20/2026 0002017526 Freenome, Inc. 35661P100 Genesis Marina, 3300 Marina Blvd Brisbane CA 94005 Rule 13d-1(c) Perceptive Advisors LLC b DE 0 10871847 0 10871847 10871847 N 10.1 IA Joseph Edelman b X1 0 10871847 0 10871847 10871847 N 10.1 IN Perceptive Life Sciences Master Fund, Ltd. b E9 0 10871847 0 10871847 10871847 N 10.1 CO Freenome, Inc. Genesis Marina, 3300 Marina Blvd, Brisbane, California , 94005 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to the Common Stock, par value $0.0001 per share (the "Common Stock") of Freenome, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 107,446,814 shares of Common Stock oustsanding as of July 20, 2026, as reported to the Reporting Persons by the Issuer. The Master Fund directly holds 10,871,847 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund and may be deemed to beneficially own shares held by the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own the shares held by the Master Fund. Perceptive Advisors: 10.1% Mr. Edelman: 10.1% Master Fund: 10.1% Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 10,871,847 Mr. Edelman: 10,871,847 Master Fund: 10,871,847 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 10,871,847 Mr. Edelman: 10,871,847 Master Fund: 10,871,847 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit 99.1 - Joint Filing Agreement Perceptive Advisors LLC /s/ Joseph Edelman 07/23/2026 Joseph Edelman /s/ Joseph Edelman 07/23/2026 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 07/23/2026