Perceptive Capital Solutions Corp

51 Astor Place, 10th Floor

New York, New York 10003

June 10, 2024

VIA EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

Office of Real Estate & Construction

100 F Street, N.E.

Washington, D.C. 20549

Attn:	Benjamin Holt and David Link
Re:	Perceptive Capital Solutions Corp
	Registration Statement on Form S-1, as amended
	Initially Filed May 21, 2024
	File No. 333-279598

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Perceptive Capital Solutions Corp (the “Company”) hereby requests acceleration of the effective date of the above referenced Registration Statement to 4:30 p.m., Eastern Time, on June 11, 2024, or as soon thereafter as practicable, or at such other time as the Company or its outside counsel, Kirkland & Ellis LLP, request by telephone that such Registration Statement be declared effective.

Please contact Mathieu Kohmann, of Kirkland & Ellis LLP, special counsel to the Company, at (212) 390-4510, as soon as the Registration Statement has been declared effective, or if you have any other questions or concerns regarding this matter.

[Signature Page Follows]

Very truly yours, Perceptive Capital Solutions Corp
By:	/s/ Sam Cohn
Name:	Sam Cohn
Title:	Chief Financial Officer

cc:

Christian O. Nagler, Kirkland & Ellis LLP

Peter Seligson, Kirkland & Ellis LLP

Mathieu Kohmann, Kirkland & Ellis LLP