X0202 SCHEDULE 13G 0000904566 XXXXXXXX LIVE Common Stock, par value $0.0001 per share 07/20/2026 0002017526 Freenome, Inc. 35661P100 Genesis Marina 3300 Marina Blvd Brisbane CA 94005 Rule 13d-1(d) Roche Holdings, Inc. b DE 0.00 18692766.00 0.00 18692766.00 18692766.00 N 17.4 CO The securities reported in Items 6, 8 and 9 herein consist of (i) 18,055,686 shares of common stock held of record by Roche Holdings, Inc. and (ii) 637,080 shares of common stock held of record by Roche Finance Ltd. The percentage in Item 11 is calculated based upon 107,446,814 shares of the Issuer's common stock outstanding as of July 20, 2026, as reported by the Issuer in its Current Report on Form 8-K, filed with the Securities and Exchange Commission on July 24, 2026. Roche Finance Ltd V8 0.00 18692766.00 0.00 18692766.00 18692766.00 N 17.4 CO The securities reported in Items 6, 8 and 9 herein consist of (i) 18,055,686 shares of common stock held of record by Roche Holdings, Inc. and (ii) 637,080 shares of common stock held of record by Roche Finance Ltd. The percentage in Item 11 is calculated based upon 107,446,814 shares of the Issuer's common stock outstanding as of July 20, 2026, as reported by the Issuer in its Current Report on Form 8-K, filed with the Securities and Exchange Commission on July 24, 2026. Roche Holding Ltd V8 0.00 18692766.00 0.00 18692766.00 18692766.00 N 17.4 CO The securities reported in Items 6, 8 and 9 herein consist of (i) 18,055,686 shares of common stock held of record by Roche Holdings, Inc. and (ii) 637,080 shares of common stock held of record by Roche Finance Ltd. The percentage in Item 11 is calculated based upon 107,446,814 shares of the Issuer's common stock outstanding as of July 20, 2026, as reported by the Issuer in its Current Report on Form 8-K, filed with the Securities and Exchange Commission on July 24, 2026. Freenome, Inc. Genesis Marina, 3300 Marina Blvd, Brisbane, CA 94005 This Schedule 13G is filed jointly by Roche Holdings, Inc., Roche Finance Ltd and Roche Holding Ltd (collectively, the "Reporting Persons"). Roche Holdings, Inc. is a wholly owned subsidiary of Roche Finance Ltd, which is a wholly owned subsidiary of Roche Holding Ltd. A Joint Filing Agreement is attached as Exhibit 99.1. Roche Holdings, Inc.: 1 DNA Way, Mailstop 49, South San Francisco, California 94080Roche Finance Ltd: Grenzacherstrasse 122, CH 4070 Basel, SwitzerlandRoche Holding Ltd: Grenzacherstrasse 124, CH 4070 Basel, Switzerland Roche Holdings, Inc.: Delaware; Roche Finance Ltd: Switzerland; Roche Holding Ltd: Switzerland Y See the responses to Item 9 on the attached cover pages. Roche Finance Ltd may be deemed to beneficially own the shares held by Roche Holdings, Inc., its wholly owned subsidiary, and Roche Holding Ltd may be deemed to beneficially own the shares held by both Roche Finance Ltd and Roche Holdings, Inc. See the responses to Item 11 on the attached cover pages. 0 See the responses to Item 6 on the attached cover pages. 0 See the responses to Item 8 on the attached cover pages. Y Y Y Y Y Y Exhibit 99.1 - Joint Filing Agreement Roche Holdings, Inc. /s/ Anjna Mehta 09/01/2026 Roche Finance Ltd /s/ Anja Harmeier 09/01/2026 /s/ Peter Trybus 09/01/2026 Roche Holding Ltd /s/ Claudia Bockstiegel 09/01/2026 /s/ Peter Trybus 09/01/2026