<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: One Fin Capital Management LP -->
          <cik>0001753875</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Class A Ordinary Shares</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>01/06/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0002017526</issuerCik>
        <issuerName>Perceptive Capital Solutions Corp</issuerName>
        <issuerCusip>G70077105</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>51 ASTOR PLACE, 10TH FLOOR</com:street1>
          <com:city>NEW YORK</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10003</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>One Fin Capital Management LP</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>603072.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>603072.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>603072.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>6.8</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
      <comments>Percentage calculated based on 8,911,250 Class A Ordinary Shares outstanding as of November 12, 2025, as reported in the Form 10-Q filed by the Issuer for the quarter ended September 30, 2025.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>One Fin Capital Master Fund LP</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>E9</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>603072.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>603072.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>603072.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>6.8</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
      <comments>Percentage calculated based on 8,911,250 Class A Ordinary Shares outstanding as of November 12, 2025, as reported in the Form 10-Q filed by the Issuer for the quarter ended September 30, 2025.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>One Fin Capital GP LLC</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>603072.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>603072.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>603072.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>6.8</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
      <comments>Percentage calculated based on 8,911,250 Class A Ordinary Shares outstanding as of November 12, 2025, as reported in the Form 10-Q filed by the Issuer for the quarter ended September 30, 2025.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>David MacKnight</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>603072.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>603072.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>603072.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>6.8</classPercent>
      <typeOfReportingPerson>HC</typeOfReportingPerson>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>Percentage calculated based on 8,911,250 Class A Ordinary Shares outstanding as of November 12, 2025, as reported in the Form 10-Q filed by the Issuer for the quarter ended September 30, 2025.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Perceptive Capital Solutions Corp</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>51 Astor Place, 10th Floor, New York, NY 10003</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>One Fin Capital Management LP, a Delaware limited partnership ("One Fin")

One Fin Capital Master Fund LP, a Cayman Islands limited partnership (the "Partnership")

One Fin Capital GP LLC, a Delaware limited liability company (the "General Partner")

David MacKnight

One Fin and the General Partner are the investment adviser and general partner, respectively, of the Partnership.  Mr. MacKnight is the control person of One Fin and the General Partner.  The reporting persons are filing this Schedule 13G jointly, but not as members of a group, and each disclaims membership in a group.  Each reporting person also disclaims beneficial ownership of Class A Ordinary Shares except to the extent of that person's pecuniary interest therein.  In addition, the filing of this Schedule 13G on behalf of the Partnership should not be construed as an admission that it is, and it disclaims that it is, a beneficial owner, as defined in Rule 13d-3 under the Act, of any Class A Ordinary Shares covered by this Schedule 13G.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>One Letterman Drive, Building C, Suite C3-400, San Francisco, CA 94129</principalBusinessOfficeOrResidenceAddress>
        <citizenship>See Item 4 of the cover sheet for each reporting person.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
        <typeOfPersonFiling>HC</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>One Fin:  603,072

Partnership:  603,072

General Partner:  603,072

David MacKnight:  603,072</amountBeneficiallyOwned>
        <classPercent>One Fin:  6.8%

Partnership:  6.8%

General Partner:  6.8%

David MacKnight:  6.8%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>One Fin:  0

Partnership:  0

General Partner:  0

David MacKnight:  0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>One Fin:  603,072

Partnership:  603,072

General Partner:  603,072

David MacKnight:  603,072</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>One Fin:  0

Partnership:  0

General Partner:  0

David MacKnight:  0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>One Fin:  603,072

Partnership:  603,072

General Partner:  603,072

David MacKnight:  603,072</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>N</notApplicableFlag>
        <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>The Partnership holds Class A Ordinary Shares for the benefit of its investors and has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, Class A Ordinary Shares.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <exhibitInfo>Exhibit 99 - Agreement Regarding Joint Filing of Statement on Schedule 13D or 13G</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>One Fin Capital Management LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ MayKao Y. Manisone</signature>
        <title>Chief Compliance Officer</title>
        <date>01/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>One Fin Capital Master Fund LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ MayKao Y. Manisone</signature>
        <title>Chief Compliance Officer of the General Partner, One Fin Capital GP LLC</title>
        <date>01/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>One Fin Capital GP LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ MayKao Y. Manisone</signature>
        <title>Chief Compliance Officer</title>
        <date>01/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>David MacKnight</reportingPersonName>
      <signatureDetails>
        <signature>/s/ David MacKnight</signature>
        <title>Reporting person</title>
        <date>01/13/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
