<?xml version="1.0" encoding="UTF-8"?><!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com --><!-- Created: Wed May 13 21:14:54 UTC 2026 --><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:common="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0000898432-26-000031</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001250077</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Class A Ordinary Shares, par value $0.0001 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0002017526</issuerCik>
        <issuerName>Perceptive Capital Solutions Corp</issuerName>
        <issuerCusips>
          <issuerCusipNumber>G70077105</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <common:street1>51 Astor Place, 10th Floor</common:street1>
          <common:city>New York</common:city>
          <common:stateOrCountry>NY</common:stateOrCountry>
          <common:zipCode>10003</common:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>CRCM INSTITUTIONAL MASTER FUND (BVI), LTD.</reportingPersonName>
      <citizenshipOrOrganization>D8</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>99600</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>99600</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>99600</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>1.1</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
      <comments>Note to Row 11: Based on 8,911,250 Class A Ordinary Shares outstanding as of March 10, 2026, reported in the Issuer's Annual Report on Form 10-K filed with the Securities and Exchange Commission on March 12, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>CRCM LP</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>116245</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>116245</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>116245</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>1.3</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
      <comments>Note to Row 11: Based on 8,911,250 Class A Ordinary Shares outstanding as of March 10, 2026, reported in the Issuer's Annual Report on Form 10-K filed with the Securities and Exchange Commission on March 12, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>CRCM LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>116245</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>116245</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>116245</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>1.3</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
      <comments>Note to Row 11: Based on 8,911,250 Class A Ordinary Shares outstanding as of March 10, 2026, reported in the Issuer's Annual Report on Form 10-K filed with the Securities and Exchange Commission on March 12, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Chun R. Ding</reportingPersonName>
      <citizenshipOrOrganization>U7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>116245</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>116245</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>116245</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>1.3</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>Note to Row 11: Based on 8,911,250 Class A Ordinary Shares outstanding as of March 10, 2026, reported in the Issuer's Annual Report on Form 10-K filed with the Securities and Exchange Commission on March 12, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Perceptive Capital Solutions Corp</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>51 Astor Place, 10th Floor, New York, New York, 10003</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>(i) CRCM Institutional Master Fund (BVI), Ltd., a British Virgin Islands limited company ("CRCM Master Fund");

(ii) CRCM LP, a Delaware limited partnership and the investment manager ("Investment Manager") of CRCM Master Fund and separately managed account clients (the "Managed Accounts");

(iii) CRCM LLC, a Delaware limited liability company and the general partner (the "General Partner") of the Investment Manager, with respect to the shares held by the CRCM Master Fund and the Managed Accounts; and

(iv) Chun R. Ding ("Ding"), a citizen of St. Kits and Nevis and the managing partner of the Investment Manager, the manager of the General Partner, with respect to the shares held by the CRCM Master Fund and the Managed Accounts.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The address of the principal business of (i) CRCM Master Fund (c/o CRCM) is 475 Sansome Street, Suite 730, San Francisco, CA 94111; (ii-iv) the Investment Manager, the General Partner, and Mr. Ding (c/o CRCM) is 475 Sansome Street, Suite 730, San Francisco, CA 94111.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>The citizenship of each Reporting Person is set forth above.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>The information required by Items 4(a) - (c) is set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</amountBeneficiallyOwned>
        <classPercent>The Class A Ordinary Shares reported hereby for the CRCM Master Fund are owned directly by the fund.  The Investment Manager, as investment manager of the CRCM Master Fund and the Managed Accounts, may be deemed to be the beneficial owner of all such shares owned by the CRCM Master Fund and the Managed Accounts.  The General Partner, as general partner of the Investment Manager, may be deemed to be the beneficial owner of all of such shares owned by the CRCM Master Fund and the Managed Accounts.  Mr. Ding, as managing partner of the Investment Manager, and manager of the General Partner with the power to exercise investment discretion, may be deemed to be the beneficial owner of all such shares owned by the CRCM Master Fund and the Managed Accounts.  Each of the Investment Manager, the General Partner and Mr. Ding hereby disclaims any beneficial ownership of any such shares.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>The information required by Items 4(a) - (c) is set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>The information required by Items 4(a) - (c) is set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>The information required by Items 4(a) - (c) is set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>The information required by Items 4(a) - (c) is set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>N</notApplicableFlag>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>CRCM INSTITUTIONAL MASTER FUND (BVI), LTD.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Chun R. Ding</signature>
        <title>Chun R. Ding</title>
        <date>05/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>CRCM LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Chun R. Ding</signature>
        <title>Chun R. Ding</title>
        <date>05/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>CRCM LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Chun R. Ding</signature>
        <title>Chun R. Ding</title>
        <date>05/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Chun R. Ding</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Chun R. Ding</signature>
        <title>Chun R. Ding</title>
        <date>05/13/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
