144 0002013809 XXXXXXXX LIVE 0001516551 Skye Bioscience, Inc. 001-42009 11250 EL CAMINO REAL, SUITE 100 SAN DIEGO CA 92130 (858) 410-0266 Diep Tuan Tu Officer Common Stock Piper Sandler & Co Inc

800 Nicollet Mall Minneapolis MN 55402

22877 126052.27 30338290 11/15/2024 Nasdaq Common Stock 11/15/2024 Compensation Issuer N 22877 11/15/2024 NA Y 11/15/2024 Alex Johnson, a duly authorized representative of Piper Sandler & Co Corporate & Venture Services FA, as attorney-in-fact for Tuan Tu Diep