<?xml version="1.0" ?>
<informationTable xsi:schemaLocation="http://www.sec.gov/edgar/document/thirteenf/informationtable eis_13FDocument.xsd" xmlns="http://www.sec.gov/edgar/document/thirteenf/informationtable" xmlns:n1="http://www.sec.gov/edgar/document/thirteenf/informationtable" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <infoTable>
    <nameOfIssuer>AGIOS PHARMACEUTICALS, INC.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00847X104</cusip>
    <value>17760750</value>
    <shrsOrPrnAmt>
      <sshPrnamt>525000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>525000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>ALUMIS INC.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>022307102</cusip>
    <value>93576170</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4247670</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4247670</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>AtaiBeckley Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>04650F101</cusip>
    <value>9735000</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2750000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2750000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Centessa Pharmaceuticals plc</nameOfIssuer>
    <titleOfClass>SPONSORED ADS</titleOfClass>
    <cusip>152309100</cusip>
    <value>54178835</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1364019</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1364019</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Celldex Therapeutics, Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>15117B202</cusip>
    <value>10020760</value>
    <shrsOrPrnAmt>
      <sshPrnamt>315913</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>315913</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CG Oncology, Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>156944100</cusip>
    <value>150349360</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2221474</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2221474</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Corvus Pharmaceuticals, Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>221015100</cusip>
    <value>26790939</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1831233</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1831233</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Crinetics Pharmaceuticals, Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>22663K107</cusip>
    <value>7700203</value>
    <shrsOrPrnAmt>
      <sshPrnamt>212010</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>212010</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Denali Therapeutics Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>24823R105</cusip>
    <value>23231443</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1209971</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1209971</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>GH Research PLC</nameOfIssuer>
    <titleOfClass>ORD</titleOfClass>
    <cusip>G3855L106</cusip>
    <value>4435818</value>
    <shrsOrPrnAmt>
      <sshPrnamt>315492</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>315492</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Hinge Health, Inc.</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>433313103</cusip>
    <value>8498624</value>
    <shrsOrPrnAmt>
      <sshPrnamt>220400</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>220400</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Jade Biosciences, Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>008064206</cusip>
    <value>4496000</value>
    <shrsOrPrnAmt>
      <sshPrnamt>320000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>320000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Kymera Therapeutics, Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>501575104</cusip>
    <value>12187992</value>
    <shrsOrPrnAmt>
      <sshPrnamt>146332</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>146332</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Minerva Neurosciences, Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>603380205</cusip>
    <value>11969265</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1986600</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1986600</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>OnKure Therapeutics, Inc.</nameOfIssuer>
    <titleOfClass>COM CL A</titleOfClass>
    <cusip>68277Q105</cusip>
    <value>5985542</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1445783</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1445783</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Verastem, Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>92337C203</cusip>
    <value>16677144</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3146631</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>3146631</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>Zura Bio Ltd</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>G9TY5A101</cusip>
    <value>2677500</value>
    <shrsOrPrnAmt>
      <sshPrnamt>450000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>450000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
</informationTable>
