144 0001778071 XXXXXXXX LIVE 0002012593 Rapport Therapeutics, Inc. 001-42121 99 HIGH STREET SUITE 2100 BOSTON MA 02110 857-321-8020 Third Rock Ventures V, L.P. 10% Stockholder Common Raymond James & Associates

880 Carillon Parkway St. Petersburg FL 33716

426005 17175115.78 47792943 04/17/2026 Nasdaq Common 02/21/2023 Original Issuance Issuer-Rapport Therapeutics, Inc. N 2803200 02/21/2023 Cash Y 04/17/2026 11/21/2025 Melissa Fisher, as duly authorized representative of Raymond James & Associates, Inc., as attorney-in-fact for Keving Gillis