144 0002022087 XXXXXXXX LIVE 0002012593 Rapport Therapeutics, Inc. 001-42121 99 High Street, Suite 2100 Boston MA 02110 857-321-8020 DAVID BREDT Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

6567 197337.69 47661138 01/02/2026 NASDAQ Common 12/31/2025 Performance Restricted Stock Units vesting under a registered plan Issuer N 6567 12/31/2025 Compensation N 10b5-1 Sales for DAVID S BREDT

99 High Street, Suite 2100 Boston MA 02110

Common 10/15/2025 8500 219195.45 10b5-1 Sales for DAVID S BREDT

99 High Street, Suite 2100 Boston MA 02110

Common 11/15/2025 8500 214090.35 10b5-1 Sales for DAVID S BREDT

99 High Street, Suite 2100 Boston MA 02110

Common 12/15/2025 8500 255130.05 Non-discretionary sale of shares to cover tax obligation from settlement of vested Performance Restricted Stock Units 01/02/2026 David Bredt