X0508 4 2025-03-13 0001228627 Opus Genetics, Inc. IRD 0002008983 Jayagopal Ashwath C/O OPUS GENETICS, INC. 8 DAVIS DRIVE, SUITE 220 DURHAM NC 27709 true Chief Scientific & Dev. Ofc. false Common Stock 2025-03-13 4 A 0 52500 0 A 125807 D Employee Stock Option (right to buy) 0.93 2025-03-13 4 A 0 52500 0 A 2035-03-12 Common Stock 52500 52500 D Represents a grant of restricted stock units which vest in four equal installments on the first, second, third and fourth anniversary of the grant date of March 13, 2025, subject to the Reporting Person's continuing service. The option will vest with respect to 25% on March 13, 2026, with the remaining shares vesting quarterly in 12 equal installments thereafter at the end of each quarter, subject to the Reporting Person's continuing service. /s/ Amy Rabourn, by Power of Attorney 2025-03-17