<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0002006495</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001865408</issuerCik>
      <issuerName>Exscientia plc</issuerName>
      <secFileNumber>001-40850</secFileNumber>
      <issuerAddress>
        <com:street1>THE SCHRODINGER BUILDING</com:street1>
        <com:street2>OXFORD SCIENCE PARK</com:street2>
        <com:city>OXFORD</com:city>
        <com:stateOrCountry>X0</com:stateOrCountry>
        <com:zipCode>OX4 4GE</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>44 0 1865 818941</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Hallett David</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Stifel Nicolaus &amp; Company Inc.</name>
        <address>
          <com:street1>501 N Broadway</com:street1>
          <com:city>St Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63102</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>20000</noOfUnitsSold>
      <aggregateMarketValue>94600.00</aggregateMarketValue>
      <noOfUnitsOutstanding>125702396</noOfUnitsOutstanding>
      <approxSaleDate>10/24/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/22/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>375000</amountOfSecuritiesAcquired>
      <paymentDate>10/24/2024</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Hallett David</name>
        <address>
          <com:street1>THE SCHRODINGER BUILDING,</com:street1>
          <com:street2>OXFORD SCIENCE PARK</com:street2>
          <com:city>OXFORD</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>OX4 4GE</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/24/2024</saleDate>
      <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
      <grossProceeds>53531.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Hallett David</name>
        <address>
          <com:street1>THE SCHRODINGER BUILDING</com:street1>
          <com:street2>OXFORD SCIENCE PARK</com:street2>
          <com:city>OXFORD,</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>OX4 4GE</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>08/26/2024</saleDate>
      <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
      <grossProceeds>59900.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Hallett David</name>
        <address>
          <com:street1>THE SCHRODINGER BUILDING</com:street1>
          <com:street2>OXFORD SCIENCE PARK</com:street2>
          <com:city>OXFORD</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>OX4 4GE</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>09/24/2024</saleDate>
      <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
      <grossProceeds>50850.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/24/2024</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>09/25/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Dominick Iadicicco, as a duly authorized representative of STIFEL, as attorney-in-fact for David Hallett</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
