144 0002005755 XXXXXXXX LIVE 0001719714 Mereo BioPharma Group plc 001-38452 4th Floor, One Cavendish Place London X0 W1G 0QF 44-333 023 7300 Fox Christine Ann Officer American Depositary Shares Representing Ordinary Shares Morgan Stanley & Co. LLC

1585 Broadway New York NY 10036-8293

28286 131812.76 769262609 09/12/2024 NASDAQ American Depositary Shares Representing Ordinary Shares 09/12/2024 Same Day Cashless Exercise and Sale Issuer N 60000 09/12/2024 Equity Compensation N Christine Ann Fox

4th Floor, One Cavendish Place London X0 W1G 0QF

American Depositary Shares Representing Ordinary Shares 06/25/2024 12990 47983.76 Christine Ann Fox

4th Floor, One Cavendish Place London X0 W1G 0QF

American Depositary Shares Representing Ordinary Shares 06/26/2024 29439 99892.41 The number of shares to be sold is in the form of American Depositary Shares ("ADSs"). The number of shares outstanding is in the form of ordinary shares. Each ADS represents 5 ordinary shares, nominal value GBP 0.003 per ordinary share, of the Issuer. Represents ADSs sold to cover tax obligations from vesting of Performance Based Restricted Share Units. 09/12/2024 /s/ Christine Ann Fox