<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0002005463</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001840706</issuerCik>
      <issuerName>SOPHiA GENETICS SA</issuerName>
      <secFileNumber>001-40627</secFileNumber>
      <issuerAddress>
        <com:street1>185 Dartmouth Street</com:street1>
        <com:street2>Floor 5</com:street2>
        <com:city>Boston</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02116</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>41216941060</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Ross Muken</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>24530</noOfUnitsSold>
      <aggregateMarketValue>121668.8</aggregateMarketValue>
      <noOfUnitsOutstanding>65230559</noOfUnitsOutstanding>
      <approxSaleDate>04/03/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <acquiredDate>04/03/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of Restricted Stock Units Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>SOPHiA GENETICS SA</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>24530</amountOfSecuritiesAcquired>
      <paymentDate>04/03/2024</paymentDate>
      <natureOfPayment>Vesting of Restricted Stock Unit Grant</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>02/18/2024</saleDate>
      <amountOfSecuritiesSold>789</amountOfSecuritiesSold>
      <grossProceeds>3716.19</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>02/22/2024</saleDate>
      <amountOfSecuritiesSold>154</amountOfSecuritiesSold>
      <grossProceeds>739.2</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>03/18/2024</saleDate>
      <amountOfSecuritiesSold>944</amountOfSecuritiesSold>
      <grossProceeds>4210.24</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>03/22/2024</saleDate>
      <amountOfSecuritiesSold>210</amountOfSecuritiesSold>
      <grossProceeds>997.5</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The Reporting Person is selling the securities set forth herein pursuant to an automatic "sell to cover" transaction that did not represent a discretionary trade by the Reporting Person in order to pay the tax liability arising from the vesting and settlement of restricted stock units.</remarks>
    <noticeSignature>
      <noticeDate>04/03/2024</noticeDate>
      <signature>/s/ Ross Muken</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
