Adobe Inc COM 00724F101 4217729 12051 SH DFND 2 12051 0 0 Agenus Inc COM NEW 00847G804 3341745 1064250 SH DFND 2 1064250 0 0 Alphabet Inc CAP STK CL A 02079K305 6480039 20703 SH DFND 2 20703 0 0 Alumis Inc COM 022307102 4880000 500000 SH DFND 2 500000 0 0 Amazon.com Inc COM 023135106 11887230 51500 SH DFND 2 51500 0 0 Apellis Pharmaceuticals Inc COM 03753U106 64769308 2578396 SH DFND 2 2578396 0 0 Arcus Biosciences Inc COM 03969F109 33242850 1395000 SH DFND 2 1395000 0 0 Arcus Biosciences Inc COM 03969F109 38415795 1612077 SH DFND 1 1612077 0 0 Arm Holdings PLC SPONSORED ADS 042068205 2350165 21500 SH DFND 2 21500 0 0 Arrowhead Pharmaceuticals Inc COM 04280A100 99616602 1500476 SH DFND 2 1500476 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 50295213 235862 SH DFND 2 235862 0 0 Benitec Biopharma Inc COM NEW 08205P209 10439250 775000 SH DFND 2 775000 0 0 BeOne Medicines AG SPONSORED ADS 07725L102 151905000 500000 SH DFND 2 500000 0 0 Bicara Therapeutics Inc COM 055477103 87801588 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