The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adobe Inc COM 00724F101   5,309,240 15,051 SH   DFND 2 15,051 0 0
Agenus Inc COM NEW 00847G804   4,097,363 1,064,250 SH   DFND 2 1,064,250 0 0
Alphabet Inc CAP STK CL A 02079K305   5,154,449 21,203 SH   DFND 2 21,203 0 0
Amazon.com Inc COM 023135106   12,844,845 58,500 SH   DFND 2 58,500 0 0
Amer Sports Inc COM SHS G0260P102   868,750 25,000 SH   DFND 2 25,000 0 0
Apellis Pharmaceuticals Inc COM 03753U106   58,349,101 2,578,396 SH   DFND 2 2,578,396 0 0
Arcus Biosciences Inc COM 03969F109   21,924,247 1,612,077 SH   DFND 1 1,612,077 0 0
Arcus Biosciences Inc COM 03969F109   17,680,000 1,300,000 SH   DFND 2 1,300,000 0 0
Arrivent Biopharma Inc COM 04272N102   12,915,000 700,000 SH   DFND 2 700,000 0 0
Arrowhead Pharmaceuticals Inc COM 04280A100   92,084,161 2,669,880 SH   DFND 2 2,669,880 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101   46,891,724 235,862 SH   DFND 2 235,862 0 0
Astera Labs Inc COM 04626A103   685,300 3,500 SH   DFND 2 3,500 0 0
Avidity Biosciences Inc COM 05370A108   56,014,028 1,285,610 SH   DFND 2 1,285,610 0 0
BeOne Medicines AG SPONSORED ADS 07725L102   167,961,693 492,990 SH   DFND 2 492,990 0 0
Bicara Therapeutics Inc COM 055477103   82,375,941 5,216,969 SH   DFND 2 5,216,969 0 0
Bicycle Therapeutics PLC SPONSORED ADS 088786108   15,578,700 2,012,752 SH   DFND 2 2,012,752 0 0
BIOAGE Labs Inc COM 09077V100   2,248,547 382,406 SH   DFND 2 382,406 0 0
Black Diamond Therapeutics Inc COM 09203E105   3,966,299 1,046,517 SH   DFND 2 1,046,517 0 0
Caribou Biosciences Inc COM 142038108   245,459 105,347 SH   DFND 2 105,347 0 0
Cartesian Therapeutics Inc COM NEW 816212302   5,756,640 563,272 SH   DFND 2 563,272 0 0
CCC Intelligent Solutions Holdings Inc COM 12510Q100   455,500 50,000 SH   DFND 2 50,000 0 0
Cellebrite DI Ltd ORDINARY SHARES M2197Q107   1,667,700 90,000 SH   DFND 2 90,000 0 0
Centessa Pharmaceuticals PLC SPONSORED ADS 152309100   78,267,287 3,227,517 SH   DFND 2 3,227,517 0 0
Chime Financial Inc COM SHS CL A 16935C109   504,250 25,000 SH   DFND 2 25,000 0 0
Chipotle Mexican Grill Inc COM 169656105   1,861,525 47,500 SH   DFND 2 47,500 0 0
Cogent Biosciences Inc COM 19240Q201   24,760,646 1,724,279 SH   DFND 2 1,724,279 0 0
Confluent Inc CLASS A COM 20717M103   742,500 37,500 SH   DFND 2 37,500 0 0
CoreWeave Inc COM CL A 21873S108   3,284,400 24,000 SH   DFND 2 24,000 0 0
Crinetics Pharmaceuticals Inc COM 22663K107   70,330,648 1,688,611 SH   DFND 2 1,688,611 0 0
CrowdStrike Holdings Inc CL A 22788C105   9,072,030 18,500 SH   DFND 2 18,500 0 0
Cullinan Therapeutics Inc COM 230031106   7,076,921 1,193,410 SH   DFND 2 1,193,410 0 0
Cyclerion Therapeutics Inc COM 23255M204   267,157 116,155 SH   DFND 2 116,155 0 0
Datadog Inc CL A COM 23804L103   4,688,520 32,925 SH   DFND 2 32,925 0 0
Denali Therapeutics Inc COM 24823R105   11,928,369 821,513 SH   DFND 2 821,513 0 0
Disc Medicine Inc COM 254604101   60,357,538 913,401 SH   DFND 2 913,401 0 0
Dynatrace Inc COM NEW 268150109   4,856,095 100,229 SH   DFND 2 100,229 0 0
Dyne Therapeutics Inc COM 26818M108   59,824,051 4,729,174 SH   DFND 2 4,729,174 0 0
Edgewise Therapeutics Inc COM 28036F105   63,210,946 3,897,099 SH   DFND 2 3,897,099 0 0
Elastic NV ORD SHS N14506104   1,056,125 12,500 SH   DFND 2 12,500 0 0
Eledon Pharmaceuticals Inc COM 28617K101   5,368,467 2,072,767 SH   DFND 2 2,072,767 0 0
Erasca Inc COM 29479A108   19,090,803 8,757,249 SH   DFND 2 8,757,249 0 0
Figma Inc CLASS A COM STK 316841105   778,050 15,000 SH   DFND 2 15,000 0 0
Foghorn Therapeutics Inc COM 344174107   3,524,321 720,720 SH   DFND 2 720,720 0 0
Generation Bio Co COM NEW 37148K209   1,816,979 296,892 SH   DFND 2 296,892 0 0
GitLab Inc CLASS A COM 37637K108   2,885,120 64,000 SH   DFND 2 64,000 0 0
Gossamer Bio Inc COM 38341P102   13,699,586 5,208,968 SH   DFND 2 5,208,968 0 0
HubSpot Inc COM 443573100   1,871,200 4,000 SH   DFND 2 4,000 0 0
IHS Holding Limited ORD SHS G4701H109   16,078,286 2,357,520 SH   DFND 1 2,357,520 0 0
I-Mab SPONSORED ADS 44975P103   4,407,317 1,165,957 SH   DFND 2 1,165,957 0 0
Instil Bio Inc COM NEW 45783C200   3,642,243 203,933 SH   DFND 2 203,933 0 0
IONQ Inc COM 46222L108   10,455,000 170,000 SH   DFND 1 170,000 0 0
IREN Ltd ORDINARY SHARES Q4982L109   938,100 20,000 SH   DFND 2 20,000 0 0
Ironwood Pharmaceuticals Inc COM CL A 46333X108   144,797 110,532 SH   DFND 2 110,532 0 0
Jfrog Ltd ORD SHS M6191J100   5,069,800 107,116 SH   DFND 2 107,116 0 0
Kalaris Therapeutics Inc COM 482929106   1,839,566 318,264 SH   DFND 2 318,264 0 0
Ke Holdings Inc SPONSORED ADS 482497104   2,755,000 145,000 SH   DFND 2 145,000 0 0
Kenvue Inc COM 49177J102   405,750 25,000 SH   DFND 2 25,000 0 0
Keurig Dr Pepper Inc COM 49271V100   1,965,546 77,050 SH   DFND 2 77,050 0 0
Korro Bio Inc COM 500946108   20,057,912 418,833 SH   DFND 2 418,833 0 0
Kymera Therapeutics Inc COM 501575104   194,033,290 3,428,150 SH   DFND 2 3,428,150 0 0
Lexeo Therapeutics Inc COM 52886X107   4,006,808 603,435 SH   DFND 2 603,435 0 0
Lexicon Pharmaceuticals Inc COM NEW 528872302   52,540,519 38,918,903 SH   DFND 2 38,918,903 0 0
Microsoft Corp COM 594918104   8,882,843 17,150 SH   DFND 2 17,150 0 0
monday.com Ltd SHS M7S64H106   1,355,830 7,000 SH   DFND 2 7,000 0 0
Nebius Group NV SHS CLASS A N97284108   8,150,802 72,600 SH   DFND 2 72,600 0 0
Neumora Therapeutics Inc COM 640979100   7,932,075 4,358,283 SH   DFND 2 4,358,283 0 0
New Oriental Education & Technology Group Inc SPON ADR 647581206   3,290,340 62,000 SH   DFND 2 62,000 0 0
NewAmsterdam Pharma Company NV ORDINARY SHARES N62509109   21,776,650 765,705 SH   DFND 2 765,705 0 0
NIQ Global Intelligence PLC ORDINARY SHARES G63755105   1,491,500 95,000 SH   DFND 2 95,000 0 0
NVIDIA Corp COM 67066G104   6,993,764 37,485 SH   DFND 2 37,485 0 0
Oric Pharmaceuticals Inc COM 68622P109   12,090,900 1,007,575 SH   DFND 1 1,007,575 0 0
Palo Alto Networks Inc COM 697435105   2,738,689 13,450 SH   DFND 2 13,450 0 0
PDD Holdings Inc SPONSORED ADS 722304102   5,736,310 43,401 SH   DFND 2 43,401 0 0
PepGen Inc COM 713317105   3,234,000 700,000 SH   DFND 2 700,000 0 0
Pinterest Inc CL A 72352L106   804,250 25,000 SH   DFND 2 25,000 0 0
Primo Brands Corp CLASS A COM SHS 741623102   1,657,500 75,000 SH   DFND 2 75,000 0 0
Procore Technologies Inc COM 74275K108   729,200 10,000 SH   DFND 2 10,000 0 0
ProQR Therapeutics NV SHS EURO N71542109   3,306,150 1,552,183 SH   DFND 2 1,552,183 0 0
Qualcomm Inc COM 747525103   2,329,040 14,000 SH   DFND 2 14,000 0 0
Rapport Therapeutics Inc COM 75383L102   31,288,029 1,053,469 SH   DFND 2 1,053,469 0 0
RAPT Therapeutics Inc COM NEW 75382E208   14,970,218 580,466 SH   DFND 2 580,466 0 0
Remitly Global Inc COM 75960P104   1,222,500 75,000 SH   DFND 2 75,000 0 0
Remitly Global Inc COM 75960P104   25,155,317 1,543,271 SH   DFND 1 1,543,271 0 0
Revolution Medicines Inc COM 76155X100   48,741,724 1,043,720 SH   DFND 2 1,043,720 0 0
Rezolute Inc COM NEW 76200L309   45,778,000 4,870,000 SH   DFND 2 4,870,000 0 0
Rhythm Pharmaceuticals Inc COM 76243J105   50,492,475 499,975 SH   DFND 2 499,975 0 0
Sagimet Biosciences Inc COM SER A 786700104   4,971,929 724,771 SH   DFND 2 724,771 0 0
SailPoint Inc COM 78781J109   1,104,000 50,000 SH   DFND 2 50,000 0 0
Salesforce Inc COM 79466L302   7,133,700 30,100 SH   DFND 2 30,100 0 0
Scholar Rock Holding Corp COM 80706P103   344,470,186 9,250,005 SH   DFND 2 9,250,005 0 0
Seer Inc COM CL A 81578P106   8,680,000 4,000,000 SH   DFND 2 4,000,000 0 0
SEMrush Holdings Inc CL A COM 81686C104   885,000 125,000 SH   DFND 2 125,000 0 0
Septerna Inc COM 81734D104   41,429,288 2,202,514 SH   DFND 2 2,202,514 0 0
ServiceNow Inc COM 81762P102   6,557,915 7,126 SH   DFND 2 7,126 0 0
Silence Therapeutics PLC ADS 82686Q101   15,110,363 2,911,438 SH   DFND 2 2,911,438 0 0
Sionna Therapeutics Inc COM 829401108   9,558,250 325,000 SH   DFND 2 325,000 0 0
Soleno Therapeutics Inc COM 834203309   31,592,319 467,342 SH   DFND 2 467,342 0 0
Solid Biosciences Inc COM NEW 83422E204   45,756,134 7,415,905 SH   DFND 2 7,415,905 0 0
Spotify Technology SA SHS L8681T102   1,516,754 2,173 SH   DFND 2 2,173 0 0
Spyre Therapeutics Inc COM NEW 00773J202   6,177,702 368,598 SH   DFND 2 368,598 0 0
Stoke Therapeutics Inc COM 86150R107   52,812,655 2,247,347 SH   DFND 2 2,247,347 0 0
Structure Therapeutics Inc SPONSORED ADS 86366E106   28,750,708 1,026,811 SH   DFND 2 1,026,811 0 0
Taboola.com Ltd ORD SHS M8744T106   33,995,978 9,969,495 SH   DFND 1 9,969,495 0 0
Taiwan Semiconductor Manufacturing Co Ltd SPONSORED ADS 874039100   7,875,978 28,200 SH   DFND 2 28,200 0 0
Tango Therapeutics Inc COM 87583X109   49,418,779 5,883,188 SH   DFND 2 5,883,188 0 0
Taysha Gene Therapies Inc COM SHS 877619106   36,018,190 11,014,737 SH   DFND 2 11,014,737 0 0
Tenax Therapeutics Inc COM NEW 88032L605   2,682,076 352,441 SH   DFND 2 352,441 0 0
Tesla Inc COM 88160R101   667,080 1,500 SH   DFND 2 1,500 0 0
Trevi Therapeutics Inc COM 89532M101   23,212,333 2,536,867 SH   DFND 2 2,536,867 0 0
Uniqure NV SHS N90064101   16,063,424 275,200 SH   DFND 2 275,200 0 0
Upstream Bio Inc COM 91678A107   14,830,745 788,450 SH   DFND 2 788,450 0 0
Vertiv Holdings Co COM CL A 92537N108   301,720 2,000 SH   DFND 2 2,000 0 0
vTv Therapeutics Inc CL A NEW 918385204   3,806,050 163,000 SH   DFND 2 163,000 0 0
WAVE Life Sciences Ltd SHS Y95308105   27,057,077 3,696,322 SH   DFND 2 3,696,322 0 0
Whitehawk Therapeutics Inc COM 00032Q104   3,955,800 2,082,000 SH   DFND 2 2,082,000 0 0
Workiva Inc COM CL A 98139A105   2,582,400 30,000 SH   DFND 2 30,000 0 0
Xenon Pharmaceuticals Inc COM 98420N105   32,632,354 812,761 SH   DFND 2 812,761 0 0