The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adobe Inc COM 00724F101   7,401,362 19,298 SH   DFND 2 19,298 0 0
Agenus Inc COM NEW 00847G804   752,500 500,000 SH   DFND 2 500,000 0 0
Alphabet Inc CAP STK CL A 02079K305   7,840,712 50,703 SH   DFND 2 50,703 0 0
Amazon.com Inc COM 023135106   10,749,690 56,500 SH   DFND 2 56,500 0 0
Apellis Pharmaceuticals Inc COM 03753U106   56,389,521 2,578,396 SH   DFND 2 2,578,396 0 0
Apogee Therapeutics Inc COM 03770N101   22,228,976 594,994 SH   DFND 2 594,994 0 0
Arcus Biosciences Inc COM 03969F109   12,654,804 1,612,077 SH   DFND 1 1,612,077 0 0
Arrowhead Pharmaceuticals Inc COM 04280A100   34,014,271 2,669,880 SH   DFND 2 2,669,880 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101   44,788,865 287,366 SH   DFND 2 287,366 0 0
Avidity Biosciences Inc COM 05370A108   32,785,207 1,110,610 SH   DFND 2 1,110,610 0 0
Beigene Ltd SPONSORED ADS 07725L102   135,728,185 498,689 SH   DFND 2 498,689 0 0
Bicara Therapeutics Inc COM 055477103   42,570,091 3,267,083 SH   DFND 2 3,267,083 0 0
Bicycle Therapeutics PLC SPONSORED ADS 088786108   15,390,264 1,812,752 SH   DFND 2 1,812,752 0 0
BILL Holdings Inc COM 090043100   1,307,865 28,500 SH   DFND 2 28,500 0 0
BIOAGE Labs Inc COM 09077V100   1,437,847 382,406 SH   DFND 2 382,406 0 0
Black Diamond Therapeutics Inc COM 09203E105   1,622,101 1,046,517 SH   DFND 2 1,046,517 0 0
Blueprint Medicines Corp COM 09627Y109   64,273,041 726,167 SH   DFND 2 726,167 0 0
Boeing Co COM 097023105   852,750 5,000 SH   DFND 2 5,000 0 0
Caribou Biosciences Inc COM 142038108   96,192 105,347 SH   DFND 2 105,347 0 0
Cartesian Therapeutics Inc COM NEW 816212302   7,423,925 563,272 SH   DFND 2 563,272 0 0
Centessa Pharmaceuticals PLC SPONSORED ADS 152309100   42,565,217 2,960,029 SH   DFND 2 2,960,029 0 0
Couchbase Inc COM 22207T101   785,138 49,850 SH   DFND 2 49,850 0 0
Crinetics Pharmaceuticals Inc COM 22663K107   56,636,013 1,688,611 SH   DFND 2 1,688,611 0 0
CrowdStrike Holdings Inc CL A 22788C105   8,814,500 25,000 SH   DFND 2 25,000 0 0
Cullinan Therapeutics Inc COM 230031106   9,034,114 1,193,410 SH   DFND 2 1,193,410 0 0
Cyclerion Therapeutics Inc COM 23255M204   290,388 116,155 SH   DFND 2 116,155 0 0
Datadog Inc CL A COM 23804L103   4,705,034 47,425 SH   DFND 2 47,425 0 0
Deckers Outdoor Corp COM 243537107   559,050 5,000 SH   DFND 2 5,000 0 0
Denali Therapeutics Inc COM 24823R105   11,168,469 821,513 SH   DFND 2 821,513 0 0
Disc Medicine Inc COM 254604101   53,207,379 1,071,865 SH   DFND 2 1,071,865 0 0
Dynatrace Inc COM NEW 268150109   4,136,422 87,729 SH   DFND 2 87,729 0 0
Dyne Therapeutics Inc COM 26818M108   28,430,144 2,717,987 SH   DFND 2 2,717,987 0 0
Edgewise Therapeutics Inc COM 28036F105   37,321,768 1,696,444 SH   DFND 2 1,696,444 0 0
Eledon Pharmaceuticals Inc COM 28617K101   2,339,676 690,170 SH   DFND 2 690,170 0 0
Erasca Inc COM 29479A108   11,997,431 8,757,249 SH   DFND 2 8,757,249 0 0
Ferrari NV COM N3167Y103   636,364 1,500 SH   DFND 2 1,500 0 0
Foghorn Therapeutics Inc. COM 344174107   2,630,628 720,720 SH   DFND 2 720,720 0 0
GDS Holdings Ltd SPONSORED ADS 36165L108   316,625 12,500 SH   DFND 2 12,500 0 0
Generation Bio Co COM 37148K100   1,202,415 2,968,925 SH   DFND 2 2,968,925 0 0
Gossamer Bio Inc COM 38341P102   5,729,865 5,208,968 SH   DFND 2 5,208,968 0 0
HOOKIPA Pharma Inc COM NEW 43906K209   611,971 566,640 SH   DFND 2 566,640 0 0
IGM Biosciences Inc COM 449585108   3,744,200 3,255,826 SH   DFND 2 3,255,826 0 0
IHS Holding Limited ORD SHS G4701H109   12,306,254 2,357,520 SH   DFND 1 2,357,520 0 0
Informatica Inc COM CL A 45674M101   872,500 50,000 SH   DFND 2 50,000 0 0
Instil Bio Inc COM NEW 45783C200   3,540,277 203,933 SH   DFND 2 203,933 0 0
Intel Corp COM 458140100   908,400 40,000 SH   DFND 2 40,000 0 0
IONQ Inc COM 46222L108   3,751,900 170,000 SH   DFND 1 170,000 0 0
Ironwood Pharmaceuticals Inc COM CL A 46333X108   162,482 110,532 SH   DFND 2 110,532 0 0
Jfrog Ltd ORD SHS M6191J100   4,211,712 131,616 SH   DFND 2 131,616 0 0
Kalaris Therapeutics Inc COM 482929106   2,269,166 282,586 SH   DFND 2 282,586 0 0
Ke Holdings Inc SPONSORED ADS 482497104   2,109,450 105,000 SH   DFND 2 105,000 0 0
Korro Bio Inc COM 500946108   7,291,883 418,833 SH   DFND 2 418,833 0 0
Kronos Bio Inc COM 50107A104   695,437 842,954 SH   DFND 2 842,954 0 0
Kymera Therapeutics Inc COM 501575104   88,687,367 3,240,313 SH   DFND 2 3,240,313 0 0
Lexeo Therapeutics Inc COM 52886X107   2,093,919 603,435 SH   DFND 2 603,435 0 0
Lexicon Pharmaceuticals Inc COM NEW 528872302   1,620,271 3,516,214 SH   DFND 2 3,516,214 0 0
LPL Financial Holdings Inc COM 50212V100   2,453,550 7,500 SH   DFND 2 7,500 0 0
Marvell Technology Inc COM 573874104   2,266,269 36,808 SH   DFND 2 36,808 0 0
Merus NV COM N5749R100   43,919,526 1,043,467 SH   DFND 2 1,043,467 0 0
Metsera Inc COM 59267L107   4,083,000 150,000 SH   DFND 2 150,000 0 0
Microsoft Corp COM 594918104   10,698,615 28,500 SH   DFND 2 28,500 0 0
MongoDB Inc CL A 60937P106   964,700 5,500 SH   DFND 2 5,500 0 0
Nebius Group NV SHS CLASS A N97284108   2,955,400 140,000 SH   DFND 2 140,000 0 0
Neumora Therapeutics Inc COM 640979100   4,358,283 4,358,283 SH   DFND 2 4,358,283 0 0
New Oriental Education & Technology Group Inc SPON ADR 647581206   3,800,895 79,500 SH   DFND 2 79,500 0 0
NewAmsterdam Pharma Company NV ORDINARY SHARES N62509109   39,139,254 1,912,030 SH   DFND 2 1,912,030 0 0
Nike Inc CL B 654106103   952,200 15,000 SH   DFND 2 15,000 0 0
NVIDIA Corp COM 67066G104   4,815,540 44,432 SH   DFND 2 44,432 0 0
Occidental Petroleum Corp COM 674599105   493,600 10,000 SH   DFND 2 10,000 0 0
Oric Pharmaceuticals Inc COM 68622P109   5,622,269 1,007,575 SH   DFND 1 1,007,575 0 0
Palo Alto Networks Inc COM 697435105   1,962,360 11,500 SH   DFND 2 11,500 0 0
PayPal Holdings Inc COM 70450Y103   1,305,000 20,000 SH   DFND 2 20,000 0 0
PDD Holdings Inc SPONSORED ADS 722304102   6,260,833 52,901 SH   DFND 2 52,901 0 0
Pegasystems Inc COM 705573103   1,147,080 16,500 SH   DFND 2 16,500 0 0
Procore Technologies Inc COM 74275K108   660,200 10,000 SH   DFND 2 10,000 0 0
ProQR Therapeutics NV SHS EURO N71542109   2,064,403 1,552,183 SH   DFND 2 1,552,183 0 0
Prothena Corporation PLC SHS G72800108   15,883,993 1,283,555 SH   DFND 2 1,283,555 0 0
Qualcomm Inc COM 747525103   2,150,540 14,000 SH   DFND 2 14,000 0 0
Rapport Therapeutics Inc COM 75383L102   3,796,044 378,469 SH   DFND 2 378,469 0 0
Reddit Inc CL A 75734B100   2,465,150 23,500 SH   DFND 2 23,500 0 0
Remitly Global Inc COM 75960P104   9,681,339 465,449 SH   DFND 1 465,449 0 0
Remitly Global Inc COM 75960P104   520,000 25,000 SH   DFND 2 25,000 0 0
Revolution Medicines Inc COM 76155X100   19,934,377 563,755 SH   DFND 2 563,755 0 0
Rhythm Pharmaceuticals Inc COM 76243J105   14,700,923 277,533 SH   DFND 2 277,533 0 0
Rocket Pharmaceuticals Inc COM 77313F106   3,943,724 591,263 SH   DFND 2 591,263 0 0
Sagimet Biosciences Inc COM SER A 786700104   2,362,753 724,771 SH   DFND 2 724,771 0 0
SailPoint Inc COM 78781J109   1,781,250 95,000 SH   DFND 2 95,000 0 0
Salesforce Inc COM 79466L302   3,918,056 14,600 SH   DFND 2 14,600 0 0
Scholar Rock Holding Corp COM 80706P103   297,387,661 9,250,005 SH   DFND 2 9,250,005 0 0
Seer Inc COM CL A 81578P106   6,760,000 4,000,000 SH   DFND 2 4,000,000 0 0
SEMrush Holdings Inc CL A COM 81686C104   1,166,250 125,000 SH   DFND 2 125,000 0 0
Septerna Inc COM 81734D104   12,752,556 2,202,514 SH   DFND 2 2,202,514 0 0
ServiceNow Inc COM 81762P102   7,265,574 9,126 SH   DFND 2 9,126 0 0
Silence Therapeutics PLC ADS 82686Q101   7,867,329 2,789,833 SH   DFND 2 2,789,833 0 0
Sionna Therapeutics Inc COM 829401108   3,399,500 325,000 SH   DFND 2 325,000 0 0
Soleno Therapeutics Inc COM 834203309   51,968,229 727,337 SH   DFND 2 727,337 0 0
Solid Biosciences Inc COM NEW 83422E204   27,438,849 7,415,905 SH   DFND 2 7,415,905 0 0
Spyre Therapeutics Inc COM NEW 00773J202   5,947,329 368,598 SH   DFND 2 368,598 0 0
StandardAero, Inc. COM 85423L103   1,514,617 56,855 SH   DFND 2 56,855 0 0
Stoke Therapeutics Inc COM 86150R107   14,944,858 2,247,347 SH   DFND 2 2,247,347 0 0
Summit Therapeutics Inc COM 86627T108   13,406,550 695,000 SH   DFND 2 695,000 0 0
Taboola.com Ltd ORD SHS M8744T106   29,410,010 9,969,495 SH   DFND 1 9,969,495 0 0
Taiwan Semiconductor Manufacturing Co Ltd SPONSORED ADS 874039100   4,731,000 28,500 SH   DFND 2 28,500 0 0
Tango Therapeutics Inc COM 87583X109   3,514,519 2,565,342 SH   DFND 2 2,565,342 0 0
Taysha Gene Therapies Inc COM SHS 877619106   9,055,484 6,514,737 SH   DFND 2 6,514,737 0 0
Tesla Inc COM 88160R101   2,332,440 9,000 SH   DFND 2 9,000 0 0
Tourmaline Bio Inc COM 89157D105   1,390,589 91,426 SH   DFND 2 91,426 0 0
Trevi Therapeutics Inc COM 89532M101   18,013,258 2,863,793 SH   DFND 2 2,863,793 0 0
Upstream Bio Inc COM 91678A107   4,825,314 788,450 SH   DFND 2 788,450 0 0
US Bancorp COM NEW 902973304   527,750 12,500 SH   DFND 2 12,500 0 0
Vaxcyte Inc COM 92243G108   11,159,704 295,543 SH   DFND 2 295,543 0 0
Vera Therapeutics Inc CL A 92337R101   17,948,128 747,216 SH   DFND 2 747,216 0 0
Vigil Neuroscience Inc COM 92673K108   3,501,374 1,967,064 SH   DFND 2 1,967,064 0 0
WAVE Life Sciences Ltd SHS Y95308105   29,866,282 3,696,322 SH   DFND 2 3,696,322 0 0
Whitehawk Therapeutics Inc COM 00032Q104   3,705,960 2,082,000 SH   DFND 2 2,082,000 0 0
Workiva Inc COM CL A 98139A105   1,328,425 17,500 SH   DFND 2 17,500 0 0
Xenon Pharmaceuticals Inc COM 98420N105   24,584,132 732,761 SH   DFND 2 732,761 0 0