ALNYLAM PHARMACEUTICALS INC COM 02043Q107 34041978 113085 SH SOLE 4792 0 108293 AVALO THERAPEUTICS INC COM NEW 05338F306 8660948 468666 SH SOLE 19854 0 448812 BIONTECH SE SPONSORED ADS 09075V102 70210878 754550 SH SOLE 31971 0 722579 GENERATE BIOMEDICINES INC COM SHS 370920100 13912335 824679 SH SOLE 42524 0 782155 INSMED INC COM PAR $.01 457669307 59688435 559824 SH SOLE 23750 0 536074 IONIS PHARMACEUTICALS INC COM 462222100 63329637 798709 SH SOLE 33833 0 764876 LEGEND BIOTECH CORP SPONSORED ADS 52490G102 34411155 1191522 SH SOLE 50484 0 1141038 MINERALYS THERAPEUTICS INC COM 603170101 23169156 858753 SH SOLE 35869 0 822884 NATERA INC COM 632307104 32295764 118975 SH SOLE 4971 0 114004 PROCEPT BIOROBOTICS CORP COM 74276L105 10497894 464920 SH SOLE 19699 0 445221 REGENERON PHARMACEUTICALS COM 75886F107 57764746 92640 SH SOLE 3925 0 88715 ROIVANT SCIENCES LTD SHS G76279101 68405473 1932904 SH SOLE 82000 0 1850904 ROYALTY PHARMA PLC SHS CLASS A G7709Q104 64806211 1155809 SH SOLE 48971 0 1106838 STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 23939987 446059 SH SOLE 18632 0 427427 VERA THERAPEUTICS INC CL A 92337R101 21404881 498832 SH SOLE 21164 0 477668