<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0002000932</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001288847</issuerCik>
      <issuerName>Five9, Inc.</issuerName>
      <secFileNumber>001-36383</secFileNumber>
      <issuerAddress>
        <com:street1>3001Bishop Drive</com:street1>
        <com:street2>Suite 350</com:street2>
        <com:city>San Ramon</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94583</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>925-201-2000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Andrew Dignan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC</name>
        <address>
          <com:street1>Executive Financial Services</com:street1>
          <com:street2>1 New York Plaza 8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2840</noOfUnitsSold>
      <aggregateMarketValue>94383.9</aggregateMarketValue>
      <noOfUnitsOutstanding>76243052</noOfUnitsOutstanding>
      <approxSaleDate>03/04/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/03/2025</acquiredDate>
      <natureOfAcquisitionTransaction>RSU's</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2840</amountOfSecuritiesAcquired>
      <paymentDate>03/03/2025</paymentDate>
      <natureOfPayment>Not Applicable</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>03/04/2025</noticeDate>
      <signature>Andrew Dignan</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
