144 0001999390 XXXXXXXX LIVE 0001228627 Opus Genetics, Inc. 001-34079 8 DAVIS DRIVE SUITE 220 DURHAM NC 27713 (984) 884-6030 Magrath George Officer Common Jefferies LLC

520 Madison Ave New York NY 10022

9475 28898.75 83000000 07/23/2026 Nasdaq Common 01/22/2026 Vested Restricted Stock Units Opus Genetics, Inc. N 9475 01/22/2026 N/A N George Magrath

8 Davis Drive Ste.220 Durham NC 27709

Opus Genetics, Inc. 04/23/2026 9511 49647.42 Shares to be sold automatically on behalf of the reporting person, as required by the Company to satisfy tax withholding that arose in connection with a vesting and settlement event from a RSU award. This transaction will not represent a discretionary trade by the reporting person. 07/23/2026 George Magrath