<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13D" xmlns:com="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>SCHEDULE 13D</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001698535</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>



</filerInfo>
</headerData>
<formData>
<coverPageHeader>
<securitiesClassTitle>Common Shares, no par value</securitiesClassTitle>
<dateOfEvent>06/24/2025</dateOfEvent>
<previouslyFiledFlag>false</previouslyFiledFlag>
<issuerInfo>
<issuerCIK>0001997377</issuerCIK>
<issuerCUSIP>46500E867</issuerCUSIP>
<issuerName>IsoEnergy Ltd.</issuerName>
<address>
<com:street1>217 Queen Street West, Suite 401</com:street1>
<com:city>Toronto</com:city>
<com:stateOrCountry>A6</com:stateOrCountry>
<com:zipCode>M5V 0R2</com:zipCode>
</address>
</issuerInfo>
<authorizedPersons>
<notificationInfo>
<personName>Attn:  Benjamin Salter</personName>
<personPhoneNum>(604) 428-4112</personPhoneNum>
<personAddress>
<com:street1>NexGen Energy Ltd.</com:street1>
<com:street2>1021 West Hastings Street, Suite 3150</com:street2>
<com:city>Vancouver</com:city>
<com:stateOrCountry>A1</com:stateOrCountry>
<com:zipCode>V6E 0C3</com:zipCode>
</personAddress>
</notificationInfo>
</authorizedPersons>
</coverPageHeader>
<reportingPersons>
<reportingPersonInfo>
<reportingPersonCIK>0001698535</reportingPersonCIK>
<reportingPersonName>NexGen Energy Ltd.</reportingPersonName>
<fundType>WC</fundType>
<citizenshipOrOrganization>A1</citizenshipOrOrganization>
<soleVotingPower>16478746</soleVotingPower>
<sharedVotingPower>0</sharedVotingPower>
<soleDispositivePower>16478746</soleDispositivePower>
<sharedDispositivePower>0</sharedDispositivePower>
<aggregateAmountOwned>16478746</aggregateAmountOwned>
<isAggregateExcludeShares>N</isAggregateExcludeShares>
<percentOfClass>30.9</percentOfClass>
<typeOfReportingPerson>CO</typeOfReportingPerson>
<commentContent>Prior to the date the Issuer became a reporting issuer, the Reporting Person held 15,278,746 shares (31.8%).  The Issuer became a reporting issuer on April 25, 2025.  On June 24, 2025, the Reporting Person acquired an additional 1,200,000 common shares, in the ordinary course of business, as part of a larger equity offering of 5,121,500 common shares by the Issuer.</commentContent>
</reportingPersonInfo>
</reportingPersons>
<items1To7>
<item1>
<securityTitle>Common Shares, no par value</securityTitle>
<issuerName>IsoEnergy Ltd.</issuerName>
<issuerPrincipalAddress>
<com:street1>217 Queen Street West, Suite 401</com:street1>
<com:city>Toronto</com:city>
<com:stateOrCountry>A6</com:stateOrCountry>
<com:zipCode>M5V 0R2</com:zipCode>
</issuerPrincipalAddress>
</item1>
<item2>
<filingPersonName>NexGen Energy Ltd.</filingPersonName>
<principalBusinessAddress>1021 West Hastings Street&#13;
Vancouver, British Columbia V6E 0C3 Canada</principalBusinessAddress>
<principalJob>Mining</principalJob>
<hasBeenConvicted>No</hasBeenConvicted>
<convictionDescription>No</convictionDescription>
<citizenship>British Columbia, Canada</citizenship>
</item2>
<item3>
<fundsSource>Working capital</fundsSource>
</item3>
<item4>
<transactionPurpose>Reporting Person previously held 15,278,746 common shares of the Issuer, approximately 31.8% of the Issuer's outstanding shares prior to the date the Issuer became a U.S. reporting Issuer.  On June 24, 2025, the Reporting Person purchased an additional 1,200,000 common shares of the Issuer, in the ordinary course of business, at a price of C$10.00 per share, in connection with a larger equity offering of 5,121,500 common shares by the Issuer (which increased the Issuer's total outstanding shares to 53,267,314 common shares).</transactionPurpose>
</item4>
<item5>
<percentageOfClassSecurities>30.9%</percentageOfClassSecurities>
<numberOfShares>16,478,746</numberOfShares>
<transactionDesc>Issuer private placement offering</transactionDesc>
<listOfShareholders>N/A</listOfShareholders>
<date5PercentOwnership>N/A</date5PercentOwnership>
</item5>
<item6>
<contractDescription>None</contractDescription>
</item6>
<item7>
<filedExhibits>None</filedExhibits>
</item7>
</items1To7>
<signatureInfo>
<signaturePerson>
<signatureReportingPerson>NexGen Energy Ltd.</signatureReportingPerson>
<signatureDetails>
<signature>/s/ Benjamin Salter</signature>
<title>Benjamin Salter, CFO of NexGen Energy Ltd.</title>
<date>06/25/2025</date>
</signatureDetails>
</signaturePerson>
</signatureInfo>
</formData>
</edgarSubmission>
