X0202 SCHEDULE 13G/A 0001104659-24-010557 0001792204 XXXXXXXX LIVE 1 Common Stock, par value $0.0001 06/30/2026 0001991792 CG Oncology, Inc. 156944100 3000 Pegasus Park Drive Suite 1640 Dallas TX 75247 Rule 13d-1(c) Foresite Capital Fund V, L.P. b DE 1079050.00 0.00 1079050.00 0.00 1079050.00 N 1.2 PN Note to Row 5: 1,079,050 shares, except that Foresite Capital Management V, LLC ("FCM V"), the general partner of Foresite Capital Fund V, L.P. ("FCF V"), may be deemed to have sole power to vote these shares, and James B.Tananbaum ("Tananbaum"), the managing member of FCM V, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 1,079,050 shares, except that FCM V, the general partner of FCF V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 88,640,375 shares of Common Stock outstanding of CG Oncology, Inc. (the "Issuer") as of August 4, 2026, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 6, 2026. Foresite Capital Management V, LLC b DE 1079050.00 0.00 1079050.00 0.00 1079050.00 N 1.2 OO Note to Row 5: 1,079,050 shares, all of which are directly owned by FCF V. FCM V, the general partner of FCF V, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 1,079,050 shares, all of which are directly owned by FCF V. FCM V, the general partner of FCF V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 88,640,375 shares of Common Stock outstanding of the Issuer as of August 4, 2026, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 6, 2026. Foresite Capital Opportunity Fund V, L.P. b DE 857550.00 0.00 857550.00 0.00 857550.00 N 1.0 PN Note to Row 5: 857,550 shares, except that Foresite Capital Opportunity Management V, LLC ("FCM Opp V"), the general partner of Foresite Capital Opportunity Fund V, L.P. ("FCF Opp V"), may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 857,550 shares, except that FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 88,640,375 shares of Common Stock outstanding of the Issuer as of August 4, 2026, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 6, 2026. Foresite Capital Opportunity Management V, LLC b DE 857550.00 0.00 857550.00 0.00 857550.00 N 1.0 OO Note to Row 5: 857,550 shares, all of which are directly owned by FCF Opp V. FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 857,550 shares, all of which are directly owned by FCF Opp V. FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 88,640,375 shares of Common Stock outstanding of the Issuer as of August 4, 2026, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 6, 2026. Foresite Capital Fund VI LP b DE 2369574.00 0.00 2369574.00 0.00 2369574.00 N 2.7 PN Note to Row 5: 2,369,574 shares, except that Foresite Capital Management VI LLC ("FCM VI"), the general partner of Foresite Capital Fund VI LP ("FCF VI"), may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 2,369,574 shares, except that FCM VI, the general partner of FCF VI, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 88,640,375 shares of Common Stock outstanding of the Issuer as of August 4, 2026, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 6, 2026. Foresite Capital Management VI LLC b DE 2369574.00 0.00 2369574.00 0.00 2369574.00 N 2.7 OO Note to Row 5: 2,369,574 shares, all of which are directly owned by FCF VI. FCM VI, the general partner of FCF VI, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 2,369,574 shares, all of which are directly owned by FCF VI. FCM VI, the general partner of FCF VI, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 88,640,375 shares of Common Stock outstanding of the Issuer as of August 4, 2026, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 6, 2026. James B. Tananbaum b X1 4306174.00 0.00 4306174.00 0.00 4306174.00 N 4.9 IN Note to Row 5: 4,306,174 shares, of which 1,079,050 shares are directly owned by FCF V, 857,550 shares are directly owned by FCF Opp V and 2,369,574 shares are directly owned by FCF VI. Tananbaum is the managing member of each of FCM V, which is the general partner of FCF V, FCM Opp V, which is the general partner of FCF Opp V, and FCM VI, which is the general partner of FCF VI. Tananbaum may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 4,306,174 shares, of which 1,079,050 shares are directly owned by FCF V, 857,550 shares are directly owned by FCF Opp V and 2,369,574 shares are directly owned by FCF VI. Tananbaum is the managing member of each of FCM V, which is the general partner of FCF V, FCM Opp V, which is the general partner of FCF Opp V, and FCM VI, which is the general partner of FCF VI. Tananbaum may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 88,640,375 shares of Common Stock outstanding of the Issuer as of August 4, 2026, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 6, 2026. CG Oncology, Inc. 3000 Pegasus Park Drive, Suite 1640, Dallas, TX 75247 This Schedule is filed by Foresite Capital Fund V, L.P., a Delaware limited partnership, Foresite Capital Management V, LLC, a Delaware limited liability company, Foresite Capital Opportunity Fund V, L.P., a Delaware limited partnership, Foresite Capital Opportunity Management V, LLC, a Delaware limited liability company, Foresite Capital Fund VI LP, a Delaware limited partnership, Foresite Capital Management VI LLC, a Delaware limited liability company and James B. Tananbaum. The foregoing entities and individuals are collectively referred to as the "Reporting Persons." c/o Foresite Capital Management 9200 Sunset Boulevard, Suite PH1 West Hollywood, CA 90069 See Row 4 of cover page for each Reporting Person. Y See Row 9 of cover page for each Reporting Person. See Row 11 of cover page for each Reporting Person. See Row 5 of cover page for each Reporting Person. See Row 6 of cover page for each Reporting Person. See Row 7 of cover page for each Reporting Person. See Row 8 of cover page for each Reporting Person. N Y N Under certain circumstances set forth in the limited partnership agreements of FCF V, FCF Opp V and FCF VI and the limited liability company agreements of FCM V, FCM Opp V and FCM VI, the partners or members, as the case may be, of each of such entities may be deemed to have the right to receive dividends from, or the proceeds from the sale of, shares of the Issuer directly or indirectly owned by each such entity of which they are a partner or member. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit A Agreement of Joint Filing The undersigned hereby agree that a single Schedule 13G (or any amendment thereto) relating to the Common Stock of the Issuer shall be filed on behalf of each of the undersigned. Note that a copy of the applicable Agreement of Joint Filing is already on file with the appropriate agencies. Foresite Capital Fund V, L.P. /s/ James B. Tananbaum 08/14/2026 Foresite Capital Management V, LLC /s/ James B. Tananbaum 08/14/2026 Foresite Capital Opportunity Fund V, L.P. /s/ James B. Tananbaum 08/14/2026 Foresite Capital Opportunity Management V, LLC /s/ James B. Tananbaum 08/14/2026 Foresite Capital Fund VI LP /s/ James B. Tananbaum 08/14/2026 Foresite Capital Management VI LLC /s/ James B. Tananbaum 08/14/2026 James B. Tananbaum /s/ James B. Tananbaum 08/14/2026