X0508 4 2025-03-07 0001124105 GYRE THERAPEUTICS, INC. GYRE 0001985496 Ye Weiguo C/O GYRE THERAPEUTICS, INC. 12770 HIGH BLUFF DRIVE, SUITE 150 SAN DIEGO CA 92130 true Chief Operating Officer false Stock Option (Right to Buy) 10.32 2025-03-07 4 A 0 300000 0 A 2035-03-07 Common Stock 300000 300000 D This option represents a right to purchase a total of 300,000 shares of the Issuer's common stock and will vest in 48 equal monthly installments through March 7, 2029, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Ruoyu Chen, as attorney-in-fact for Weiguo Ye 2025-03-11